Vascular Ring

Congenital vascular malformation in which the AORTA arch and its branches encircle the TRACHEA and ESOPHAGUS. Signs and symptoms include DYSPNEA; RESPIRATORY SOUNDS, especially with eating, DYSPHAGIA, persistent cough, and GASTROESOPHAGEAL REFLUX or may be asymptomatic. Two most common types are double aortic arch and right aortic arch. It may be associated with other anomalies (e.g., DIGEORGE SYNDROME).

Also Known As:

Networked: 510 relevant articles (5 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia)
2.	Coronary Artery Disease (Coronary Atherosclerosis)
3.	Patent Ductus Arteriosus
4.	Fistula
5.	Vascular Ring

Experts

1.	Barton, Matthias: 4 articles (06/2007 - 08/2002)
2.	Zhang, Suli: 3 articles (01/2020 - 03/2014)
3.	Liu, Huirong: 3 articles (01/2019 - 03/2014)
4.	Uchida, Hiroo: 3 articles (01/2017 - 08/2014)
5.	Ishikawa, Yoshihiro: 3 articles (07/2014 - 09/2009)
6.	Pertz, Heinz H: 3 articles (10/2013 - 01/2008)
7.	Niu, Chun-Yu: 3 articles (07/2013 - 04/2012)
8.	Wei, Yan-Ling: 3 articles (07/2013 - 04/2012)
9.	Zhang, Yu-Ping: 3 articles (07/2013 - 04/2012)
10.	Zhao, Zi-Gang: 3 articles (07/2013 - 04/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Ring:

1.	Monoamine Oxidase (MAO)IBA 09/01/2019 - "Incubation of the adipose tissue samples and vascular rings with the MAO-A inhibitor (clorgyline, 30 min) improved vascular reactivity and decreased ROS generation. " 11/01/2017 - "The effect of increasing concentrations (10, 30, 100 μmol/L) of the irreversible MAO-A inhibitor, clorgyline, and MAO-B inhibitor, selegiline, on endothelial-dependent relaxation (EDR) in response to cumulative doses of acetylcholine was studied in isolated phenylephrine-preconstricted vascular rings. " 09/01/2023 - "Vascular rings were prepared and acutely incubated (12 h) with high glucose (GLUC, 400 mg/dL) or angiotensin II (AII, 100 nM) and metformin (10 µM) and/or empagliflozin (10 µM) and used for the assessment of MAO expression (qRT-PCR and immune histochemistry), reactive oxygen species (ROS, confocal microscopy and spectrophotometry), and vasomotor function (myograph). "
2.	IndazolesIBA 08/01/2011 - "In vitro, the stimulation of GC by 3(5'hydroxymethyl-2'furyl)-1-benzyl indazole (YC-1) (a benzyl indazole derivative) and the inhibition of PDE 5 by T-1032 were less effective in pulmonary vascular rings from CDH animals. " 08/01/1999 - "Pretreatment of vascular rings with ODQ induced a parallel, 2-log-order shift to the right of the concentration-response curves (CRCs) to histamine, ATP, NO, the NO-donors S-nitrosoglutathione, S-nitroso-N-acetyl-D,L-penicillamine, and spermine NONOate [N-[4-[1-(3-amino propyl)-2-hydroxy-2-nitroso hydrazino]butyl]-1, 3-propane diamine], and the direct sGC-stimulant [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] YC-1 but did not affect relaxations induced by papaverine and atriopeptin II. Moreover, the rightward shift of the CRCs to Angeli's salt, peroxynitrite, and linsidomine was similar to that of NO. These results suggested that ODQ is specific for sGC. "
3.	Clorgyline (Clorgiline)IBA 09/01/2019 - "Incubation of the adipose tissue samples and vascular rings with the MAO-A inhibitor (clorgyline, 30 min) improved vascular reactivity and decreased ROS generation. " 11/01/2017 - "The effect of increasing concentrations (10, 30, 100 μmol/L) of the irreversible MAO-A inhibitor, clorgyline, and MAO-B inhibitor, selegiline, on endothelial-dependent relaxation (EDR) in response to cumulative doses of acetylcholine was studied in isolated phenylephrine-preconstricted vascular rings. "
4.	T 1032IBA 08/01/2011 - "In vitro, the stimulation of GC by 3(5'hydroxymethyl-2'furyl)-1-benzyl indazole (YC-1) (a benzyl indazole derivative) and the inhibition of PDE 5 by T-1032 were less effective in pulmonary vascular rings from CDH animals. "
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/22/2009 - "This study was designed to examine whether NAC would relax vascular rings in vitro via nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, extracellular Ca2+ and/or K+ channels. " 07/01/1996 - "Methylene blue (MB) is a widely used putative inhibitor of nitric oxide (NO)-dependent responses, particularly in cell culture and vascular ring studies. " 08/01/2015 - "Vasodilatation response of vascular rings to carbachol, which induces nitric oxide (NO) mediated vasodilatation, was designated as the measure of endothelial function. " 09/01/2012 - "Nitric oxide (NO) production and nuclear transcription factor kappa B expression in vascular rings were measured. " 12/01/2002 - "It was shown that when added to the bath solution (100 microg/ml), PCL effectively restored endothelium-dependent ACh relaxations of isolated vascular rings damaged resulting from gamma-irradiation but had no effect on endothelium-independent vascular responses to therapeutic nitric oxide (NO) donors. "
6.	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/01/2021 - "Aortic vascular rings (AVRs) from OVX+ISO exhibited a significant increase in contractility in response to phenylephrine than AVRs isolated from Sham+ISO rats. " 10/29/2020 - "Mb (100 µg/mL) reduced the vascular contractility induced by phenylephrine (PE), and caused a dose-dependent relaxation of PE-induced contraction of aortic vascular rings. " 11/01/2018 - "ICN relaxed both endothelium-intact and endothelium-denuded rat vascular rings precontracted with phenylephrine or KCl in a dose-dependent manner. " 04/01/2012 - "Furthermore, phenylephrine-induced vasoconstriction was significantly increased in vascular rings of the femoral artery of KO mice. " 04/01/2010 - "Contractile responses to phenylephrine (Phe) and different Ca(2+) concentrations were recorded, respectively, from intact and chemically permeabilized vascular rings from aorta, tail and mesenteric arteries. "
7.	Acetylcholine (Acetylcholine Chloride)FDA Link 09/01/2023 - "Ex vivo stimulation with GLUC or AII increased both MAOs expression, ROS production and impaired relaxation to acetylcholine (ACh) of the vascular rings. " 03/28/2015 - "Endothelium-dependent vasodilation in response to acetylcholine (Ach) was compared ex vivo for pulmonary vascular rings from 29 smokers and 10 never-smokers. " 07/01/2014 - "Vasorelaxation to acetylcholine was significantly attenuated in vascular rings from ATP2B1(+/-) mice. " 06/01/2011 - "The acetylcholine (Ach)-dependent relaxation of superior mesenteric artery was detected using in vitro vascular ring. " 08/18/2005 - "Using isolated vascular ring tension detecting technique, cumulative relaxation responses of femoral arteries to 10(-8) - 10(-4) mol/L acetylcholine (ACh) were measured. "
8.	SmokeIBA 09/01/1999 - "The purpose of this study was to determine the physiologic effects of cigarette smoke exposure and dietary cholesterol on the availability of nitric oxide in carotid vascular rings. " 05/01/1997 - "The purpose of this study was to determine the physiologic effects of cigarette smoke exposure and dietary cholesterol on the availability of nitric oxide in aortic vascular rings. "
9.	Nifedipine (Adalat)FDA LinkGeneric 06/01/2000 - "The vascular rings were divided into two groups: control group (no nifedipine) and study group (nifedipine, 10(-6) mol/l). " 12/01/2016 - "In contraction studies, with nifedipine present (10 μM) to abolish L-ICa contribution to phenylephrine (PE)-induced vasoconstrictions of vascular rings, a marked increase in tone was observed with menthol, similar to resting (i.e., without α-adrenoceptor stimulation by PE) conditions, when L-type channels were mostly deactivated. "
10.	Guanosine Monophosphate (5' Guanylic Acid)IBA 05/22/2009 - "This study was designed to examine whether NAC would relax vascular rings in vitro via nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, extracellular Ca2+ and/or K+ channels. " 02/01/2003 - "In studies, the authors measured tissue cyclic guanosine monophosphate (cGMP) by radioimmunoassay after incubating vascular rings obtained from freshly killed baboons (1) with increasing concentrations of SNP and (2) after SNP exposure following preincubation with the radiocontrast agent, iohexhol. "

Therapies and Procedures

1.	Thoracotomy 05/01/1989 - "Left thoracotomy provides excellent exposure for all vascular rings except the displaced innominate artery, for which a right thoracotomy is the best approach." 01/01/2017 - "This study is a retrospective review of patients with double aortic arch or right aortic arch with aberrant left subclavian artery and left ligamentum (RAA with LSCA/LL) who underwent division via left thoracotomy or VATS approach at a single institution. " 03/15/1995 - "This study evaluated our early experience with video-assisted thoracoscopic vascular ring division and compared this approach with division by means of a conventional open thoracotomy. " 01/01/2021 - "An initial left-sided exploratory thoracotomy was unsuccessful in identifying and treating a vascular ring anomaly. " 01/01/2021 - "Indeed, at the age of 10 months, this patient underwent anterior arch division and posterior aortopexy via a posterolateral thoracotomy in order to relieve the compression caused by the vascular ring. "
2.	Replantation 02/01/2006 - "We report a 2-year-old child who underwent surgical repair of vascular ring and subclavian reimplantation, where use of NIRS helped in early detection and timely intervention to prevent prolonged cerebral ischemia." 01/01/2019 - "Resection of Kommerell Diverticulum and Reimplantation of Aberrant Left Subclavian Artery in Right Aortic Arch Vascular Ring." 07/01/2007 - "Report of a surgical treatment for vascular ring (right aortic arch and the anomalous origin of the left subclavian artery) related to Kommerell diverticulum with resection of the ligamentum arteriosum (ductus arteriosus), suture of the Kommerell diverticulum, and reimplantation of left subclavian artery in the ipsilateral carotid artery through left thoracotomy in a 13-year-old female." 11/01/2005 - "She underwent successful surgical repair via right thoracotomy, including division of the vascular ring, resection of the diverticulum and aneurysm, and finally reimplantation of the right subclavian artery to the aortic arch. " 08/01/2021 - "Intraoperative fluorescence angiography (IOFA) was performed using indocyanine green in patients undergoing the following procedures: coronary artery reimplantation, coronary artery unroofing, evaluation of intraoperative coronary anatomy, reoperation requiring ventriculotomy, coarctation/interrupted aortic arch repair, systemic-to-pulmonary artery shunt, Norwood procedure, thoracic duct localization, and vascular rings. "
3.	Hepatectomy 01/01/2018 - "To investigate safety and efficacy of temporary portal hemodynamics modulation with a novel percutaneously adjustable vascular ring (MID-AVR) onto a porcine model of 75% hepatectomy. " 01/01/2018 - "Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model."
4.	Therapeutics 05/01/2002 - "The purpose of this study was to review the imaging findings of children referred for cross-sectional imaging to evaluate persistent airway symptoms after surgical therapy for double aortic arch. " 01/01/2019 - "Successful Surgical Therapy of a Double Aortic Arch in a 10-Month-Old Mixed Breed Dog." 07/01/2015 - "We herein report the cases of two patients with persistent airway symptoms after surgical therapy for a double aortic arch. " 01/01/2004 - "The clinical presentation, diagnostic workup, and surgical therapy of a coarcted right-sided aortic arch associated with a vascular ring are described." 05/01/2002 - "Airway narrowing is clearly shown on cross-sectional imaging in patients with persistent airway symptoms after surgical therapy for double aortic arch. "
5.	Prostheses and Implants (Prosthesis) 11/01/1988 - "A method was developed for the noninvasive insertion of a vascular ring prostheses aimed at preserving arterial patency and preventing restenosis following angioplasty. " 05/01/1980 - "The surgical indications are discussed and the different techniques reviewed:--resection and end-to-end anastomosis,--tubular prosthesis,--associated procedures for double aortic arch. " 11/01/1988 - "Biological performance of TiNi shape memory alloy vascular ring prostheses: a two year study." 08/01/1984 - "Surgery consisted of resection and direct suture in 16 cases, implantation of a Dacron prosthesis in 7 cases, isthmoplasty in 1 case, aortotomy-graft in 1 case, insertion of a Dacron tube between the left subclavian artery and the descending thoracic aorta in 1 case; finally, one patient presented with a rare form of coarctation in a double aortic arch and was treated by a bypass from the brachiocephalic trunk to the descending thoracic aorta. " 07/01/1986 - "Nonsurgical implantation of a vascular ring prosthesis using thermal shape memory Ti/Ni alloy (Nitinol wire)."