ADAM12 Protein

A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Moses, Marsha A: 2 articles (06/2011 - 12/2004)
2.	Roy, Roopali: 2 articles (06/2011 - 12/2004)
3.	Zurakowski, David: 2 articles (06/2011 - 12/2004)
4.	Wewer, Ulla M: 2 articles (12/2006 - 12/2004)
5.	Kondo, Naru: 1 article (05/2022)
6.	Murakami, Yoshiaki: 1 article (05/2022)
7.	Okada, Kenjiro: 1 article (05/2022)
8.	Otsuka, Hiroyuki: 1 article (05/2022)
9.	Sakoda, Takuya: 1 article (05/2022)
10.	Seo, Shingo: 1 article (05/2022)

Related Diseases

1.	Knee Osteoarthritis 02/01/2012 - "Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers." 02/01/2012 - "The purpose of this study was to investigate the relationship between ADAM12-S protein and radiographic knee osteoarthritis (KOA) and its correlation to several bone and cartilage biomarkers. "
2.	Neoplasms (Cancer) 05/01/2022 - "A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) has been reported to influence tumor progression and chemosensitivity in human cancers. " 12/15/2006 - "Using immunohistochemistry, we found ADAM12 protein expression correlated with tumor stage and grade. " 06/01/2011 - "The increased expression of ADAM12 protein in the tumor cells and stroma of benign breast diseases was immunohistochemically confirmed. " 07/01/2015 - "In tumor sections, the ADAM12 protein and mRNA were expressed in epithelial cancer cells and surrounding stromal cells. " 02/01/2023 - "In patients with breast cancer, the levels of serum ADAM12 protein and mRNA were significantly higher in tumor stages than that in HDs (p < 0.05), with AUC value of 0.82. "
3.	Breast Neoplasms (Breast Cancer) 03/04/2015 - "Importantly, both miR-29b/c and miR-200b/c strongly decreased steady state levels of ADAM12-L protein in all breast cancer cell lines tested. " 06/10/2011 - "We have previously reported that urinary ADAM12 is predictive of disease status in breast cancer patients and that ADAM12 protein levels in urine increase with progression of disease. " 12/03/2004 - "Densitometric analyses of immunoblots demonstrated that ADAM 12 protein levels were higher in urine from breast cancer patients than in control urine. " 02/01/2023 - "In patients with breast cancer, the levels of serum ADAM12 protein and mRNA were significantly higher in tumor stages than that in HDs (p < 0.05), with AUC value of 0.82. " 06/10/2011 - "ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis."
4.	Peripheral Arterial Disease 01/01/2017 - "We recently showed that a disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) is upregulated in ischemic endothelial cells and plays a key role in post-ischemic angiogenesis and perfusion recovery following experimental peripheral arterial disease. "
5.	Osteophyte 02/01/2012 - "The ADAM12-S protein could be elevated in some KOA cases, and this elevation correlates with the grades of the disease, mostly owning to development of osteophytes. " 02/01/2012 - "We also found a correlation between ADAM12-S protein and osteophytes in TF and/or PF joints (P = 0.003). "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Messenger RNA (mRNA)
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Chemokine CCL3
5.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
6.	Galectin 1 (LGALS1)
7.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
8.	Protein Isoforms (Isoforms)
9.	E-Selectin
10.	Insulin-Like Growth Factor Binding Protein 1

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)