Deubiquitinating Enzymes

12/15/2022 - "Previous studies have implicated the deubiquitinase UCHL5 was abnormally expressed in multiple malignancies. "
12/02/2022 - "Together, the results presented in our study are the first to expose USP27X as a major CCND1 deubiquitinase and provide a mechanistic explanation for how this DUB fosters tumor growth. "
01/01/2022 - "In this study, we found that increased expression of the proteasomal deubiquitinase USP14 and UCHL5 in primary cancer cells from CML patients compared to healthy donors. "
01/01/2022 - "In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and positively associated with poor prognosis in multiple cohorts. "
01/01/2022 - "In this study, we observed that several OTU members displayed genomic amplification in PCa, among which ovarian tumor deubiquitinase 6A (OTUD6A) amplified in the top around 15-20%. "

01/01/2023 - "Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis."
01/01/2018 - "The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis."
01/01/2023 - "Here, we observed that deubiquitinase USP15 expression was upregulated in the livers of mice fed a high-fat diet (HFD) and liver biopsies of patients with NAFLD or NASH. "
01/01/2023 - "These results suggest that the expression of USP33, an important deubiquitinating enzyme, is increased in NAFLD fibrosis. "
01/01/2018 - "Ubiquitin specific protease 4 (USP4), a deubiquitinating enzyme, is pivotally involved in regulating multiple inflammatory pathways; however, the role of USP4 in NAFLD is unknown. "

01/01/2014 - "Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma."
06/01/2022 - "Recent studies have revealed that several deubiquitinating enzymes (DUBs) play important roles in hepatocellular carcinoma (HCC) progression, but the roles of Otubain 2 (OTUB2) in HCC remain obscure. "
04/05/2022 - "This study aimed to investigate the role of deubiquitinating enzyme 3 (DUB3) in the regulation of Krüppel-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC). "
01/01/2016 - "In this study, we investigated the effects of the deubiquitinating enzyme USP22 on the expression of the drug-resistance genes BMI1 and EZH2 in hepatocellular carcinoma (HCC) and on prognosis. "
11/28/2023 - "The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP."

05/18/2018 - "This is the first report of deubiquitinating enzyme targeting as a strategy in prostate cancer treatment which we show to be effective in multiple, currently incurable models of this disease."
01/01/2019 - "Taken together, these studies show that STAMBPL1 depletion induces apoptosis by promoting XIAP lysosomal degradation, and suggest that targeting deubiquitinase STAMBPL1 might offer promising therapeutic strategy for prostate cancer."
06/01/2019 - "Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics."
01/01/2019 - "Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation."
01/01/2019 - "Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis."

01/01/2023 - "Role of Deubiquitinases in Parkinson's Disease-Therapeutic Perspectives."
01/01/2022 - "Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease."
01/01/2020 - "Deubiquitinating Enzymes in Parkinson's Disease."
12/24/2019 - "Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients."
03/25/2011 - "The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1."