Beclin-1

An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.

Also Known As:

Networked: 2157 relevant articles (87 outcomes, 276 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Levine, Beth: 24 articles (01/2021 - 12/2003)
2.	Li, Wei: 14 articles (06/2022 - 06/2013)
3.	Zhang, Yu: 12 articles (12/2021 - 08/2015)
4.	Dent, Paul: 12 articles (11/2020 - 07/2009)
5.	Sadoshima, Junichi: 10 articles (01/2022 - 03/2007)
6.	Zhang, Lei: 10 articles (12/2021 - 09/2009)
7.	Zhang, Wei: 9 articles (12/2022 - 07/2013)
8.	Liu, Ying: 9 articles (06/2022 - 05/2014)
9.	Li, Ling: 9 articles (01/2022 - 05/2009)
10.	Booth, Laurence: 9 articles (11/2020 - 10/2013)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2022 - "Our results have demonstrated that the combined restoration of miR-424-5p and miR-142-3p is more effective in inhibiting tumor proliferation via upregulating Bax and Beclin-1 and downregulating Bcl-2 and c-Myc. " 02/14/2018 - "Robust Anticancer Efficacy of a Biologically Synthesized Tumor Acidity-Responsive and Autophagy-Inducing Functional Beclin 1." 03/01/2009 - "Suppression of Beclin-1 and Atg5 improved the survival of HAMLET-treated tumor cells and inhibited the increase in granular LC3-GFP staining. " 11/19/2022 - "The study was carried out to investigate the prognostic value of Beclin 1, EGFR and ALK for this cancer. " 01/01/2020 - "In the present study, we have identified "SEC23A-S1008-BECLIN1-autophagy axis" in the autophagic regulation of metastatic colonization step, a mechanism that tumor cells can exploit autophagy to exert self-restrain for clonogenic proliferation before the favorable tumor microenvironment is established. "
2.	Fibrosis (Cirrhosis) 06/01/2016 - "The results showed that 1) OT induced adverse cardiac structure changes but did not affect the cardiac weight index; 2) OT increased cardiac fibrosis and apoptosis and induced autophagosome formation with upregulated LC3 II/I and Beclin-1 expression; 3) TEAS preconditioning effectively alleviated OT-induced cardiac structure changes, fibrosis, apoptosis, and autophagy; 4) TEAS preconditioning produced better protective effects than TEAS postconditioning or TENAS preconditioning. " 01/01/2023 - "Enhancing autophagy via Beclin-1 improved renal outcomes with diminished fibrosis, via underlying mechanisms of differential regulation of inflammatory mediators and control of maladaptive ISR." 06/21/2013 - "Surprisingly, diabetes-induced cardiac damage was substantially attenuated in beclin 1- and Atg16-deficient mice as shown by improved cardiac function as well as reduced levels of oxidative stress, interstitial fibrosis, and myocyte apoptosis. " 11/22/2022 - "In the present study, we found that TGF-β1-mediated upregulation of UHRF1 repressed beclin 1 via methylated induction of its promoter, which finally resulted in fibroblast activation and lung fibrosis both in vitro and in vivo. " 08/24/2023 - "Expression levels of the autophagy markers LC3B, p62, and Beclin-1, and the expression levels of the fibrosis markers α-SMA, FN-1, and TGF-β1 were determined by western blot, and the levels of inflammatory factors TNF-α and IL-1β in the supernatants were assessed by ELISA. "
3.	Starvation 01/01/2020 - "EPCs function was significantly improved, autophagy fluorescence intensity was enhanced, and the level of Beclin1, Atg5, LC3 II/I also increased after starvation in vitro, and the effects were blocked by autophagy inhibitor. " 05/01/2008 - "Consistently, induction of autophagy by serum starvation offered significant protection against zVAD-induced cell death, whereas knockdown of Atg5, Atg7 or Beclin 1 markedly sensitized zVAD-induced cell death in L929 cells. " 03/22/2023 - "We demonstrated that the inhibitory AKT-mediated phosphorylation of beclin-1 and the BCL2-beclin-1 complex concur to reduce autophagosomes formation in response to starvation. " 01/01/2022 - "Compared to the control group, starvation significantly upregulated LC3-II and Beclin1 in TM cells after 3 h of stimulation, which peaked at 6 h and 9 h, respectively. " 01/01/2022 - "By using Beclin1+/- , Fundc1 knockout (KO) and Fundc1 transgenic (TG) mouse models, combined with starvation and MI models, we found that Fundc1 KO caused more severe mitochondrial and cardiac dysfunction damages than Beclin1+/- after MI. "
4.	Ischemia 01/01/2011 - "GRb1 also restored the elevation of LC3 and Beclin 1. Our work suggests that intranasal GRb1 exerts brain-targeting effects and that a single dose of intranasal GRb1 immediately after MCAO ameliorates ischemia/reperfusion insult. " 03/01/2022 - "In conclusion, Ischemia neither enhanced nor inhibited Beclin-1/LC3-II-dependent canonical macroautophagy both in vitro and in vivo, in contradiction to previous studies. " 07/21/2015 - "And the time course studies suggested that the Beclin-1 and mTOR may have coordinated regulation in ischemia stages but not in reperfusion stages. " 12/01/2023 - "Furthermore, treatment with 0.2 or 0.5 mg/kg Tat-CCT2 facilitated ischemia-induced autophagic activity and ameliorated ischemia-induced autophagic initiation in the hippocampus 1 d after ischemia based on western blotting for LC3B and Beclin-1, respectively. " 01/01/2023 - "Western blot testing showed that at the molecular level, DF significantly suppressed ischemia-induced activated expression of LC3, Beclin1, Atg12, and Atg5. "
5.	Inflammation (Inflammations) 04/01/2022 - "Autophagy/inflammation-related markers as Atg5, LC-3II/LC-3I, Beclin-1, NLRP3, IL-1β, and Caspase-1 were also measured in the present study. " 07/01/2023 - "Oxidative stress mediated mitochondrial division/fusion imbalance, further induced inflammation and autophagy via OPA1/NF-κB-COX-2-TNF-α-Beclin1 and OPA1/NF-κB-COX-2-TNF-α/P62 pathways under Cd treatment. " 10/01/2022 - "Levels of markers of autophagy (LC3B, Beclin1, Atg5) or inflammation (IL-1 beta, TNF-α) were significantly higher 72 h after ICH than at baseline, as were the numbers of TUNEL-positive cells. " 01/01/2021 - "This article reviews several chemical compounds that have been shown to regulate DOX-induced inflammation, apoptosis, and autophagy via inhibition of ER stress signaling pathways, such as the IRE1α/ASK1/JNK, IRE1α/JNK/Beclin-1, and CHOP pathways." 09/15/2020 - "Inflammation (IL-1β, IL-6, IL-8 and TNF-α) and autophagy (beclin-1, LC3 and DRAM) indicators were measured. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Caspase 3 (Caspase-3)
3.	Sirolimus (Rapamycin)
4.	Autophagy-Related Proteins
5.	TOR Serine-Threonine Kinases
6.	Biomarkers (Surrogate Marker)
7.	Peptides (Polypeptides)
8.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
9.	Beclin-1
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Cardiopulmonary Resuscitation (CPR)
3.	Resuscitation
4.	Intravenous Injections
5.	Drug Therapy (Chemotherapy)