endotrophin

01/01/2023 - "We demonstrated that neutralizing endotrophin antibody treatment significantly ameliorates renal fibrosis at the transcriptional, morphological, and functional levels. "
01/01/2023 - "Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model."
01/01/2023 - "Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTRs: results from two prospective cohort studies."
04/01/2021 - "There was no significant association between serum levels of endotrophin and advanced fibrosis. "
04/01/2021 - "Associations between endotrophin and the presence of NASH and advanced fibrosis were investigated alone and in combination with standard clinical parameters using logistic regression. "

01/01/2022 - "MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation."
01/01/2022 - "Adipocyte-specific Hif1α knock-out (APN-HIF1αKO) mice fed a chronic high-fat diet exhibited the significant amelioration of both local fibro-inflammation in AT and systemic insulin resistance compared with their control littermates, partly through the inhibition of endotrophin generation. "
01/01/2021 - "Beyond the structural role of Col6a3, overexpression of endotrophin in obese mice further augmented insulin resistance, which was tightly associated with a significant increase in lipolysis, inflammation, and cellular apoptosis in adipose tissues, whereas this showed a limited effect on adipogenesis. "
01/01/2020 - "In addition, endotrophin can also recruit macrophages and endothelial cells through chemotaxis to regulate the tumor microenvironment and ultimately promote tumor inflammation and angiogenesis. "
12/01/2016 - "Previously, we demonstrated that endotrophin serves as a costimulator to trigger fibrosis and inflammation within the unhealthy AT milieu. "

01/01/2022 - "MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation."
01/01/2023 - "High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity."
01/01/2022 - "Adipocyte-specific Hif1α knock-out (APN-HIF1αKO) mice fed a chronic high-fat diet exhibited the significant amelioration of both local fibro-inflammation in AT and systemic insulin resistance compared with their control littermates, partly through the inhibition of endotrophin generation. "
01/01/2021 - "We demonstrated that endotrophin level is higher in patients with polycystic ovary syndrome and may have predicted polycystic ovary syndrome with increased homeostasis model assessment for insulin resistance index. "
01/01/2021 - "According to our regression analyses [area under the curve: 0.973 (0.935-1.000), 95% confidence interval, 95.2% sensitivity, and 100% specificity], it was shown that endotrophin greater than 92 ng/ml and homeostasis model assessment for insulin resistance greater than 2.5 might be good predictors for polycystic ovary syndrome diagnosis. "

01/01/2020 - "The biological functions of endotrophin in tumors can be driven by adipocytes. "
01/01/2019 - "Human endotrophin as a driver of malignant tumor growth."
01/01/2019 - "High levels of COL6A3 and its cleaved product, endotrophin (ETP) in tumor-neighboring regions are strongly associated with poor prognosis in HCC patients. "
11/01/2012 - "Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. "
11/01/2012 - "Adipocyte-derived endotrophin promotes malignant tumor progression."

06/01/2019 - "This study is the first to evaluate the relationship between endotrophin and heart failure. "
06/01/2019 - "Endotrophin levels were found to be low in patients with heart failure with mid-range EF who were using RAAS blockers. "
06/01/2019 - "Serum endotrophin levels in patients with heart failure with reduced and mid-range ejection fraction."
06/01/2019 - "In this study, we aimed to investigate the role of endotrophin in the pathogenesis of cardiac fibrosis by determining its levels in patients with heart failure with reduced and mid-range ejection fraction (EF). "
01/01/2023 - "Small Peptide, Large Implications: Endotrophin in Heart Failure with Preserved Ejection Fraction."