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4-methylesculetin

has antiinflammatory activity

Networked: 7 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        4-methylesculetin: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        4-methylesculetin: 7

Experts

1.	Witaicenis, Aline: 4 articles (01/2020 - 07/2010)
2.	Di Stasi, Luiz C: 3 articles (01/2020 - 07/2010)
3.	Tanimoto, Alexandre: 2 articles (01/2020 - 01/2018)
4.	Araujo, Gabriela C: 1 article (01/2020)
5.	Caruso, Ícaro P: 1 article (01/2020)
6.	Cornélio, Marinonio L: 1 article (01/2020)
7.	Fossey, Marcelo C: 1 article (01/2020)
8.	Moraes, Fábio R: 1 article (01/2020)
9.	Piva, Hémily M R: 1 article (01/2020)
10.	Souza, Fátima P: 1 article (01/2020)

Related Diseases

1.	Inflammation (Inflammations) 01/05/2020 - "4-methylesculetin (4 ME) is a natural antioxidant coumarin with protective effects on the intestinal inflammation, in which oxidative stress plays a key role in its aetiology and pathophysiology. " 01/25/2018 - "4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation."
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/30/2010 - "Our results reveal that these compounds, particularly 4-methylesculetin, may be effective for the treatment of intestinal inflammatory bowel disease. " 01/25/2018 - "Recent studies have shown that 4-methylesculetin has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease. "
3.	Colitis 01/05/2012 - "In conclusion, 4-methylesculetin showed similar efficacy to that obtained with either prednisolone or sulphasalazine, both in the acute phase of colitis as well as following a curative protocol. " 07/30/2010 - "Similar effects were produced by the administration of 4-methylesculetin, which also inhibited the myeloperoxidase and alkaline phosphatase activities in the acute intestinal inflammatory process and in the model of colitis relapse. " 07/30/2010 - "Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis." 01/05/2012 - "After colitis relapse, 4-methylesculetin improved the colonic inflammatory status as evidenced by histological findings, with a reduction in apoptosis, as well as biochemically by inhibition of colonic myeloperoxidase, alkaline phosphatase and metalloproteinase 9 activities. " 07/30/2010 - "In light of the antioxidant and anti-inflammatory properties of esculetin and 4-methylesculetin, the aim of this study was to investigate the effects of these compounds in an experimental model of rat colitis induced by trinitrobenzenesulphonic acid (TNBS). "
4.	Metabolic Syndrome (Dysmetabolic Syndrome X) 09/09/2022 - "Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation."
5.	Traumatic Shock 07/01/1958 - "[Experimental and clinical use of disodium salt of 4-methylesculetin disulfuric ester in treatment of traumatic shock in 400 cases]."

Related Drugs and Biologics

1.	Antioxidants
2.	Peroxidase (Myeloperoxidase)
3.	Alkaline Phosphatase
4.	coumarin
5.	Metalloproteases (Metalloproteinases)
6.	Dextran Sulfate
7.	Coumarins
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Acids
10.	esculetin