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Endotoxin Hyporesponsiveness

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Immune System Diseases: 4321
- Immunologic Deficiency Syndromes: 91
  - Endotoxin Hyporesponsiveness: 13
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Pattern Recognition Receptors: 3733
        Toll-Like Receptors: 8851
        Toll-Like Receptor 4: 4031
        Endotoxin Hyporesponsiveness: 13

Related Diseases

1.	Sepsis (Septicemia)
2.	Endotoxemia
3.	Critical Illness (Critically Ill)
4.	Septic Shock (Toxic Shock Syndrome)

Experts

1.	Burch, Lauranell H: 2 articles (04/2005 - 09/2003)
2.	Davis, R Duane: 2 articles (04/2005 - 09/2003)
3.	Herczyk, Walter F: 2 articles (04/2005 - 09/2003)
4.	Palmer, Scott M: 2 articles (04/2005 - 09/2003)
5.	Reinsmoen, Nancy L: 2 articles (04/2005 - 09/2003)
6.	Schwartz, David A: 2 articles (04/2005 - 09/2003)
7.	Allen, Meredith L: 1 article (10/2006)
8.	Elliott, Martin: 1 article (10/2006)
9.	Goldman, Allan: 1 article (10/2006)
10.	Hoschtitzky, J Andreas: 1 article (10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endotoxin Hyporesponsiveness:

1.	Interleukin-10 (Interleukin 10)IBA 10/01/2006 - "This study was undertaken to delineate the relationship between observed levels of the anti-inflammatory cytokine interleukin-10, common genetic polymorphisms that influence these levels, and the occurrence and severity of endotoxin hyporesponsiveness in children following elective cardiac surgery requiring cardiopulmonary bypass. "
2.	CytokinesIBA 10/01/2006 - "This study was undertaken to delineate the relationship between observed levels of the anti-inflammatory cytokine interleukin-10, common genetic polymorphisms that influence these levels, and the occurrence and severity of endotoxin hyporesponsiveness in children following elective cardiac surgery requiring cardiopulmonary bypass. "
3.	Acetylcysteine (Siran)FDA LinkGeneric 03/01/2005 - "In this study, we have investigated the effect of N-acetylcysteine (NAC) on the early markers of leukocyte activation and subsequent endotoxin hyporesponsiveness. " 03/01/2005 - "N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness."
4.	Toll-Like Receptor 4IBA 04/01/2005 - "In support of this idea, we have recently demonstrated that lung recipients heterozygous for either of two functional polymorphisms (Asp299Gly or Thr399Ile) in Toll-like receptor 4 (TLR4) associated with endotoxin hyporesponsiveness have decreased acute rejection over the first 6 months after transplant. " 04/01/2001 - "Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium." 09/15/2003 - "To investigate the role of innate immunity in the development of allograft rejection, we assessed the impact of two functional polymorphisms in the toll-like receptor 4 (TLR4) associated with endotoxin hyporesponsiveness on the development of acute rejection after human lung transplantation. " 12/01/2002 - "Toll-like receptor 4 (TLR4) is the principal receptor for bacterial endotoxin recognition, and functional variants in the gene confer endotoxin-hyporesponsiveness in humans. "
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/2001 - "CVVH ameliorated the initial serum tumor necrosis factor-alpha response and prevented sepsis-induced in vitro endotoxin hyporesponsiveness. " 11/01/2002 - "Endotoxin hyporesponsiveness, suggested by the dissociation of decreasing TNF-alpha levels and increasing endotoxemia in end-stage sepsis, was favorably influenced by CVVH. " 03/01/2003 - "Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness."
6.	EndotoxinsIBA 04/01/2003 - "Preconditioning with low doses of endotoxin has been shown to induce endotoxin hyporesponsiveness. " 12/01/2002 - "Toll-like receptor 4 (TLR4) is the principal receptor for bacterial endotoxin recognition, and functional variants in the gene confer endotoxin-hyporesponsiveness in humans. " 03/01/2003 - "Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness."
7.	UbiquitinIBA 03/01/2003 - "Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness."
8.	Lipid AIBA 07/01/2003 - "Preconditioning pigs with low doses of monophosphoryl lipid A (MPL), a non toxic derivate of lipid A, has been shown to induce endotoxin hyporesponsiveness and to reduce the metabolic and hemodynamic consequences of endotoxin shock. "
9.	HLA-DR Antigens (HLA-DR)IBA 05/01/2001 - "Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery."
10.	GangliosidesIBA 02/01/1995 - "Altered macrophage ganglioside accessibility appears sometimes as a consequence, but not a cause, of C3H/HeJ endotoxin hyporesponsiveness."

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/01/2006 - "This study was undertaken to delineate the relationship between observed levels of the anti-inflammatory cytokine interleukin-10, common genetic polymorphisms that influence these levels, and the occurrence and severity of endotoxin hyporesponsiveness in children following elective cardiac surgery requiring cardiopulmonary bypass. "
2.	Lung Transplantation 09/15/2003 - "To investigate the role of innate immunity in the development of allograft rejection, we assessed the impact of two functional polymorphisms in the toll-like receptor 4 (TLR4) associated with endotoxin hyporesponsiveness on the development of acute rejection after human lung transplantation. "
3.	Resuscitation 03/01/2005 - "N-Acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness."