Pattern Recognition Receptors

A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.

Also Known As:

Networked: 3733 relevant articles (29 outcomes, 138 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zipfel, Cyril: 35 articles (11/2022 - 08/2005)
2.	Netea, Mihai G: 30 articles (01/2019 - 11/2005)
3.	Brown, Gordon D: 23 articles (01/2021 - 04/2005)
4.	Song, Linsheng: 21 articles (07/2021 - 01/2009)
5.	Wang, Lingling: 21 articles (07/2021 - 01/2009)
6.	Joosten, Leo A B: 20 articles (10/2020 - 04/2009)
7.	Akira, Shizuo: 20 articles (01/2017 - 03/2004)
8.	Bowie, Andrew G: 19 articles (01/2021 - 10/2005)
9.	Mantovani, Alberto: 16 articles (01/2021 - 07/2004)
10.	Zhou, Jian-Min: 16 articles (01/2021 - 04/2008)

Related Diseases

1.	Porcine Reproductive and Respiratory Syndrome (PRRS) 10/01/2021 - "In this study, we investigated several genotypes of pattern recognition receptors (PRRs) and their impact on therapeutic efficacy in LARC patients treated with CCRT. " 01/01/2016 - "Because recognition and clearance of inhaled particulates and microbes are largely mediated by pattern recognition receptors (PRRs) on the surface of AM, we hypothesized that exposure to SiO2 limits the ability of AM to respond to bacterial challenge by altering PRR expression. " 06/01/2022 - "Although the underlying mechanisms remain to be fully established, several studies point towards the involvement of activation of pattern recognition receptors (PRRs). " 03/01/2021 - "This study compares Metarhizium rileyi conidia and hyphal bodies with respect to elicitation of the immune response of Helicoverpa armigera and recognition by host pattern recognition receptors (PRRs). " 01/01/2020 - "This study describes a method developed for predicting pattern recognition receptors (PRRs), which are an integral part of the immune system. "
2.	Inflammation (Inflammations) 01/01/2017 - "Studies show that the presence of trace amounts of host cells and process-related impurities that stimulate pattern recognition receptors (PRR) can cause local inflammation and enhance product immunogenicity. " 12/01/2009 - "Here, we will review the studies on PTX3, which emphasize its role as a multifunctional soluble pattern recognition receptor acting as a non-redundant component of the humoral arm of innate immunity involved in fine-tuning inflammation, matrix deposition, angiogenesis and, in particular, in female fertility." 11/01/2006 - "In this study, we examined the potential role in gouty inflammation of CD14, a phagocyte-expressed pattern recognition receptor that functionally interacts with both TLR2 and TLR4. " 12/01/2023 - "Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregulation of signalling from pattern recognition receptors, such as TLRs. " 02/01/2023 - "Cellular damage after blood flow restoration in the heart promotes sterile inflammation through the release of molecules that activate pattern recognition receptors, among which TLR4 is the most prominent. "
3.	Infections 09/01/2013 - "The murine Plasmodium berghei ANKA (PbA) infection model has helped to identify crucial players in the pathogenesis of CM. However, the role of pattern recognition receptors in innate immunity to CM induction is still poorly understood. " 11/01/2018 - "In this study, we found that NEURL3 could be upregulated upon HCV infection in a manner dependent on pattern recognition receptor-mediated innate immune response. " 01/01/2017 - "In this study, we found that the expression of PTX3, a soluble form of pattern recognition receptor, was induced by infection with live Pseudomonas aeruginosa or treatment of cells with its supernatant. " 04/01/2015 - "In this study, we describe the mechanism by which group II IFNs are activated in response to NNV infection in a zebrafish cell line, by focusing on the relationship between type I IFNs and pattern recognition receptors. " 02/01/2015 - "The aim of this study was to identify small-molecular agonists of the pattern recognition receptor (PRR)-mediated innate immune response to control HBV infection. "
4.	Neoplasms (Cancer) 11/01/2023 - "Prior studies have defined multiple, but inconsistent, roles for the enigmatic pattern recognition receptor NLRX1 in regulating several cancer-associated biological functions. " 08/01/2009 - "The study by Besch et al. in this issue of the JCI now demonstrates that agents designed to stimulate the innate immune system by activating intracellular pattern recognition receptors can kill cancer cells in a direct, cell-autonomous fashion (see the related article beginning on page 2399). " 05/15/2007 - "These studies support the clinical development of immunotherapeutic approaches in cancer using pattern recognition receptor targeting systems for the selective delivery of tumor Ags to APCs." 09/25/2023 - "The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor or as a pro-tumor mediator depending on tumor context. " 03/01/2023 - "Further, in tumor tissues consisting of a variety of cell types, LMO2 level indicated intratumoral endothelium and pattern recognition receptor (PRR) response in both LGGs and GBMs, and additionally indicated cytotoxic T-lymphocyte, M2 macrophage infiltration and fibroblast specifically in LGGs. "
5.	Autoimmune Diseases (Autoimmune Disease) 07/01/2004 - "Indeed, several inflammatory autoimmune diseases have been linked during the past few years to defects or polymorphisms of genes encoding pattern recognition receptors. " 02/01/2008 - "Indeed, deficiencies and/or knock-out mouse studies have highlighted critical roles for soluble pattern recognition receptors in the clearance of apoptotic bodies and protection from autoimmune diseases along with mediating protection from specific infections. " 06/01/2015 - "The activation of some pattern recognition receptors (PRRs) in response to ERVs has been described in mice and in the context of human autoimmune diseases. " 01/12/2021 - "We describe the role of known pattern recognition receptors in nucleic acid sensing of LINE-1 and Alu and the possible consequences for autoimmune diseases." 01/01/2021 - "Sensing of pathogenic nucleic acids by pattern recognition receptors (PRR) not only initiates anti-microbe defense but causes inflammatory and autoimmune diseases. "

Related Drugs and Biologics

1.	Toll-Like Receptors (Toll-Like Receptor)
2.	Cytokines
3.	Proteins (Proteins, Gene)
4.	Ligands
5.	Vaccines
6.	Complement System Proteins (Complement)
7.	PTX3 protein
8.	Antibodies
9.	Amyloid (Amyloid Fibrils)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Fecal Microbiota Transplantation
4.	Ligation
5.	Drug Therapy (Chemotherapy)