Familial Thymoma

Rare, low-grade epithelial thymoma that occurs in young children and may be associated with somatic mutations in the GTF2I gene. OMIM: 274230

Also Known As:

Thymoma, Familial; Thymic Neoplasia

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Site: 4
  - Thoracic Neoplasms: 44
    - Thymus Neoplasms: 380
      - Thymoma: 4866
        Familial Thymoma: 6
- Neoplasms by Histologic Type: 2
  - Complex and Mixed Neoplasms
    - Thymoma: 4866
      - Familial Thymoma: 6
Hemic and Lymphatic Diseases: 6
- Lymphatic Diseases: 92
  - Thymus Neoplasms: 380
    - Thymoma: 4866
      - Familial Thymoma: 6

Related Diseases

1.	Thymoma (Thymic Carcinoma)
2.	Skin Diseases (Skin Disease)
3.	Opportunistic Infections (Opportunistic Infection)
4.	Neoplasms (Cancer)
5.	Myasthenia Gravis

Experts

1.	Berman, Arlene: 1 article (12/2010)
2.	Browne, Sarah K: 1 article (12/2010)
3.	Burbelo, Peter D: 1 article (12/2010)
4.	Ching, Kathryn H: 1 article (12/2010)
5.	Ding, Li: 1 article (12/2010)
6.	Giaccone, Giuseppe: 1 article (12/2010)
7.	Holland, Steven M: 1 article (12/2010)
8.	Hsu, Amy P: 1 article (12/2010)
9.	Iadarola, Michael J: 1 article (12/2010)
10.	Klimavicz, Caitlin M: 1 article (12/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Thymoma:

1.	AutoantibodiesIBA 12/02/2010 - "Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia." 07/01/2004 - "The pathogenesis of this skin disease in association with thymic neoplasia remains obscure, and our results contradict the hypothesis of production of autoantibodies that cross-react with epithelial antigens. " 12/02/2010 - "To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). "
2.	CytokinesIBA 12/02/2010 - "Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia." 12/02/2010 - "To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). "
3.	VimentinIBA 09/01/1997 - "In order to determine the histogenesis of the thymic neoplasia we used immunohistochemical techniques specific for different markers: cytokeratins, vimentin, desmin and neuron specific enolase. "
4.	Phosphopyruvate Hydratase (Enolase)IBA 09/01/1997 - "In order to determine the histogenesis of the thymic neoplasia we used immunohistochemical techniques specific for different markers: cytokeratins, vimentin, desmin and neuron specific enolase. "
5.	MitogensIBA 11/01/1980 - "(3) Lymphocytes from thymic neoplasia display an increased response to both mitogens regardless of the histologic pattern of the tumor studied. "
6.	LuciferasesIBA 12/02/2010 - "To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). "
7.	DesminIBA 09/01/1997 - "In order to determine the histogenesis of the thymic neoplasia we used immunohistochemical techniques specific for different markers: cytokeratins, vimentin, desmin and neuron specific enolase. "
8.	AntigensIBA 07/01/2004 - "The pathogenesis of this skin disease in association with thymic neoplasia remains obscure, and our results contradict the hypothesis of production of autoantibodies that cross-react with epithelial antigens. "
9.	N 30IBA 12/02/2010 - "To better understand the presence and function of anti-cytokine autoantibodies, we created a luciferase immunoprecipitation system panel to search for autoantibodies against 39 different cytokines and examined plasma from controls (n = 30) and patients with thymic neoplasia (n = 17). "

Therapies and Procedures

1.	Thymectomy 05/01/2005 - "The thoracoscopic thymectomy was indicated for: myasthenia gravis without thymic neoplasia (141 cases), stage I Masaoka thymoma (8 cases), remnant postoperative thymic tissue (3 cases). "
2.	Therapeutic Abortion 07/01/1992 - "Therapeutic abortion should be considered in the pregnant woman with known thymic neoplasia."