Tuftsin Deficiency

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Primary Immunodeficiency Diseases: 1189
    - Tuftsin Deficiency: 7
Immune System Diseases: 4321
- Immunologic Deficiency Syndromes: 91
  - Primary Immunodeficiency Diseases: 1189
    - Tuftsin Deficiency: 7
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        Tuftsin Deficiency: 7
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        Tuftsin Deficiency: 7
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        Tuftsin Deficiency: 7
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        Tuftsin Deficiency: 7
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        Tuftsin Deficiency: 7
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        Tuftsin Deficiency: 7
- Peptides: 82426
  - Oligopeptides: 519
    - Tuftsin: 144
      - Tuftsin Deficiency: 7
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        Tuftsin Deficiency: 7

Related Diseases

1.	Sepsis (Septicemia)
2.	Infections
3.	Sickle Cell Anemia (Hemoglobin S Disease)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tuftsin Deficiency:

1.	Immunoglobulins (Immunoglobulin)IBA 01/01/1997 - "There is a decrease in immunoglobulin IgM and T-lymphocytes, primary antibody response to antigen challenge is impaired, altered opsonic function an Tuftsin deficiency are noted. " 01/17/1993 - "There is a decrease in immunoglobulin IgM, T-lymphocytes, impaired primary antibody response to antigen challenge, an altered opsonic function and a tuftsin deficiency. " 10/01/1981 - "Characteristically, there is a decrease in immunoglobulin IgM, properdin, and T-lymphocytes; impaired primary antibody response to antigen challenge; an altered opsonic function; and a tuftsin deficiency. "
2.	Immunoglobulin M (IgM)IBA 01/01/1997 - "There is a decrease in immunoglobulin IgM and T-lymphocytes, primary antibody response to antigen challenge is impaired, altered opsonic function an Tuftsin deficiency are noted. " 01/17/1993 - "There is a decrease in immunoglobulin IgM, T-lymphocytes, impaired primary antibody response to antigen challenge, an altered opsonic function and a tuftsin deficiency. " 10/01/1981 - "Characteristically, there is a decrease in immunoglobulin IgM, properdin, and T-lymphocytes; impaired primary antibody response to antigen challenge; an altered opsonic function; and a tuftsin deficiency. "
3.	AntigensIBA 01/01/1997 - "There is a decrease in immunoglobulin IgM and T-lymphocytes, primary antibody response to antigen challenge is impaired, altered opsonic function an Tuftsin deficiency are noted. " 01/17/1993 - "There is a decrease in immunoglobulin IgM, T-lymphocytes, impaired primary antibody response to antigen challenge, an altered opsonic function and a tuftsin deficiency. " 10/01/1981 - "Characteristically, there is a decrease in immunoglobulin IgM, properdin, and T-lymphocytes; impaired primary antibody response to antigen challenge; an altered opsonic function; and a tuftsin deficiency. "
4.	TuftsinIBA 06/01/1985 - "We conclude that tuftsin deficiency plays a role in postsplenectomy sepsis and that treatment with synthetic tuftsin protects the splenectomized host against pneumococcal septic death."
5.	ProperdinIBA 10/01/1981 - "Characteristically, there is a decrease in immunoglobulin IgM, properdin, and T-lymphocytes; impaired primary antibody response to antigen challenge; an altered opsonic function; and a tuftsin deficiency. "
6.	Peptides (Polypeptides)IBA 08/01/1979 - "Congenital tuftsin deficiency usually arises when the peptide is mutated to an inactive peptide. "
7.	Indicators and Reagents (Reagents)IBA 07/01/1980 - "Tuftsin deficiency is an indicator of splenic hypofunction and may contribute to the increased susceptibility of patients with sickle cell disease to severe infection."

Therapies and Procedures

1.	Splenectomy 03/01/1987 - "Tuftsin deficiency and activity decreased in opsonization after splenectomy. "