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Properdin

A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
Also Known As:
Factor P, Complement; Complement Factor P
Networked: 352 relevant articles (4 outcomes, 23 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Song, Wen-Chao: 7 articles (12/2013 - 01/2008)
2. Miwa, Takashi: 4 articles (04/2013 - 01/2008)
3. Meri, Seppo: 4 articles (01/2012 - 05/2005)
4. Cortes, Claudio: 3 articles (06/2013 - 07/2010)
5. Zhou, Lin: 3 articles (01/2013 - 01/2008)
6. Kimura, Yuko: 3 articles (01/2013 - 01/2008)
7. Stover, Cordula: 3 articles (05/2012 - 04/2010)
8. Stover, Cordula M: 3 articles (02/2012 - 03/2008)
9. Schwaeble, Wilhelm J: 3 articles (02/2012 - 03/2008)
10. Lesher, Allison M: 2 articles (12/2013 - 01/2013)

Related Diseases

1. Infection
2. Convalescence
3. Reperfusion Injury
4. Kidney Diseases (Kidney Disease)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Complement System Proteins (Complement)
2. Antigen-Antibody Complex (Immune Complex)
3. Lipopolysaccharides
4. Anaphylatoxins
5. CD55 Antigens (Decay Accelerating Factor)
6. Immunoglobulin A (IgA)
7. Immunoglobulin G (IgG)
8. Antibodies
9. Complement Factor B (Factor B)
10. Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1. Homologous Transplantation (Allograft)
2. Radiotherapy
3. Aftercare (After-Treatment)
4. Transplants (Transplant)
5. Ligation

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