N- (4- methyl- 3- (1- methyl- 7- (6- methylpyridin- 3- ylamino)- 2- oxo- 1,2- dihydropyrimido(4,5- d)pyrimidin- 3(4H)- yl)phenyl)- 3- (trifluoromethyl)benzamide

a T315I-Bcr-Abl antagonist; structure in first source

Also Known As:

BRAF inhibitor GNF-7; Bcr-Abl antagonist GNF-7; gnf-7; gnf-7 compound

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - N-(4-methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido(4,5-d)pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide: 7
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - N-(4-methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido(4,5-d)pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide: 7

Experts

1.	Sim, Taebo: 5 articles (04/2021 - 05/2015)
2.	Shin, Injae: 4 articles (04/2021 - 01/2018)
3.	Ju, Eunhye: 3 articles (04/2021 - 01/2018)
4.	Jeon, Eunhye: 2 articles (04/2021 - 01/2021)
5.	Kim, Namkyoung: 2 articles (04/2021 - 01/2021)
6.	Kim, Younghoon: 2 articles (04/2021 - 01/2021)
7.	Lee, Jiwon: 2 articles (04/2021 - 01/2021)
8.	Nam, Yunju: 2 articles (01/2021 - 11/2020)
9.	Gray, Nathanael S: 2 articles (01/2018 - 05/2015)
10.	Cho, Wonjeong: 1 article (04/2021)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 01/01/2020 - "The Bcr-Abl inhibitor GNF-7 inhibits necroptosis and ameliorates acute kidney injury by targeting RIPK1 and RIPK3 kinases."
2.	Neoplasms (Cancer) 01/01/2021 - "We herein report novel and potent mtRAS-signaling pathway blockers, SIJ1795 and SIJ1772, possessing 2 to 10-fold increased anti-proliferative activities compared to those of GNF-7 on cancer cells harboring mtRAS as well as on Ba/F3 cells transformed with mtRAS. " 01/01/2018 - "Moreover, 10k possessing a favorable mouse pharmacokinetic profile prolonged life-span of Ba/F3-NRAS-G12D injected mice and significantly delayed tumor growth of OCI-AML3 xenograft model without causing the prominent level of toxicity found with GNF-7. " 11/05/2020 - "In addition, GNF-7 and SIJ1227 suppress more strongly migration/invasion of these cancer cells than vemurafenib and PLX8394. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/30/2023 - "GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia." 05/14/2015 - "One of the compounds identified, GNF-7, potently and selectively inhibited NRAS-dependent cells in preclinical models of acute myelogenous leukemia and acute lymphoblastic leukemia. "
4.	Melanoma (Melanoma, Malignant) 04/06/2021 - "Novel and most potent derivative, SIJ1777, possesses not only two-digit nanomolar potency but also 2 to 14-fold enhanced anti-proliferative activities compared with reference compound, GNF-7 against melanoma cells (SK-MEL-2, SK-MEL-28, A375, WM3670, WM3629). " 04/06/2021 - "Taken together, our six GNF-7 derivatives exhibit highly potent activities against melanoma cells harboring class I/II/III BRAF mutations compared with vemurafenib as well as PLX8394." 11/05/2020 - "Compared with vemurafenib and PLX8394, both GNF-7 and SIJ1227 possess much more strong anti-proliferative activities on melanoma (A375 and C8161) and lung cancer cells (H1755 and H1666) harboring BRAF V600E (class I mutant), BRAF G464E/G469A (class II mutant) and BRAF G466V (class III mutant), respectively. " 11/05/2020 - "Also, both GNF-7 and SIJ1227 are capable of inhibiting more strongly colony formation than vemurafenib and PLX8394 in 3D soft agar assay using C8161 melanoma cells. "
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/14/2015 - "One of the compounds identified, GNF-7, potently and selectively inhibited NRAS-dependent cells in preclinical models of acute myelogenous leukemia and acute lymphoblastic leukemia. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Vemurafenib
3.	PLX8394
4.	Cisplatin (Platino)
5.	Agar