|1.||Hiipakka, Richard A: 7 articles (04/2011 - 11/2004)|
|2.||Liao, Shutsung: 7 articles (04/2011 - 11/2004)|
|3.||Kokontis, John M: 5 articles (04/2011 - 11/2004)|
|4.||Chuu, Chih-Pin: 4 articles (09/2010 - 11/2004)|
|5.||Getz, Godfrey S: 3 articles (04/2011 - 11/2008)|
|6.||Reardon, Catherine A: 3 articles (04/2011 - 11/2008)|
|7.||Peng, Dacheng: 3 articles (04/2011 - 11/2008)|
|8.||Bramanti, Placido: 3 articles (02/2010 - 01/2010)|
|9.||Cuzzocrea, Salvatore: 3 articles (02/2010 - 01/2010)|
|10.||Crisafulli, Concetta: 3 articles (02/2010 - 01/2010)|
10/01/2015 - "The results of the present study suggested that ligand T0901317 promotes LXR‑α expression, which consequently suppresses LPS‑induced inflammation by elevating NOR‑1 expression in KCs."
07/01/2015 - "This study investigates whether LXR agonist T0901317 may modulate viral replication and cardiac inflammation during VM. "
05/01/2009 - "Pre-treatment with T0901317 before LPS stimulation can suppress the expressions of IRF3 and GRIP1 to inhibit the inflammation and hence Kupffer cell activation."
01/01/2010 - "Administration of T0901317, 30 min after the challenge with carrageenan, caused a significant reduction in a dose dependent manner of all the parameters of inflammation measured. "
02/24/2015 - "Coadministration of the LXR agonist T0901317 with the Mer-neutralizing antibody inhibited the aggravating effects of the antibody on inflammation in mice. "
|2.||HIV Infections (HIV Infection)
09/01/2015 - "Pre-exposure of peripheral blood leukocytes to T0901317 provided only a short-term protection against HIV infection. "
09/01/2015 - "Pre-exposure of monocyte-derived macrophages to T0901317 reduced susceptibility of these cells to HIV infection in vitro. "
09/01/2015 - "In this study, we extended these observations by analyzing the effect of the LXR agonist T0901317 [N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide] on the ongoing HIV infection and investigating the possibility of using LXR agonist for pre-exposure prophylaxis of HIV infection in a humanized mouse model. "
01/01/2014 - "T0901317 treatment induced significant insulin resistance in C57BL/6 mice. "
01/01/2013 - "The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance."
01/01/2013 - "Twice weekly intraperitoneal injections of T0901317 at 50 mg/kg in animals on the same diet completely blocked obesity development, obesity-associated insulin resistance, and glucose intolerance. "
01/01/2013 - "Treatment of high fat diet-induced obese mice with T0901317, an LXR activator, or fenofibrate, the PPARα agonist, or in combination alleviated insulin resistance and improved glucose tolerance. "
01/01/2014 - "Insulin-sensitizing effect of T0901317 was not related to changes in intramuscular level of lipid mediators of insulin resistance, since neither diacylglycerols nor ceramide content was affected by the treatment. "
08/01/2010 - "This anti-HIV activity was dependent on ABCA1, because the effect of the drug was significantly reduced in ABCA1-defective T cells from a patient with Tangier disease, and RNA interference-mediated inhibition of ABCA1 expression eliminated the effect of TO-901317 on HIV-1 replication. "
12/01/2011 - "Chronic administration of T0901317 significantly reduced atherosclerosis in HC diet-fed rabbits despite less favorable lipid profiles, i.e. "
12/01/2011 - "Finally, we tested T0901317 in the atherosclerosis intervention study. "
01/01/2010 - "Thus, MHEC relative to T0901317 may be a better therapeutic LXR agonist for the treatment of atherosclerosis."
03/01/2009 - "T0901317 treatment decreased atherosclerosis with a much more pronounced response and dose dependence in the innominate artery than in the aortic sinus. "
04/01/2015 - "Meanwhile, the combination of T0901317 and U0126 inhibited the development of atherosclerosis in a synergistic manner and reduced advanced lesions. "
|4.||liver X receptor
|6.||NF-kappa B (NF-kB)
|10.||Palmitic Acid (Hexadecanoic Acid)
|3.||Heterologous Transplantation (Xenotransplantation)