onapristone

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37 relevant articles (2 outcomes, 8 trials/studies) found for this Bio-Agent

Description: induces vaginal bleeding and luteal regression in monkeys; structure given in first source; progesterone antagonist

Also Known As:

11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one; ZK 299; ZK 98.299; ZK 98299; ZK-299; ZK-98299; Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(3-hydroxypropyl)-, (11beta,13alpha,17alpha)-

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 58

Steroids: 13691

Gonanes: 2

onapristone: 37

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 02/01/2008 - "STUDY DESIGN: Controls (group 1: n = 4) and preterm labor models (group 2: n = 4, treated with onapristone) were used" 04/01/1998 - "4) The characteristics of onapristone-induced preterm labor are generally similar to those of spontaneous term labor" 09/01/1997 - "Preterm labor was induced with the administration of a single injection of the antiprogestin onapristone (10 mg)" 07/01/1996 - "On day 17 of gestation groups of animals were injected subcutaneously with a single dose of either 3 or 30 mg/kg onapristone; animals were monitored for preterm labor and delivery for up to 48 hours" 04/01/1998 - "STUDY DESIGN: Electrical activity during pregnancy (nonlabor, days 18 to 22), term labor (day 22), and preterm labor (onapristone injected on day 18, delivery on day 19) was measured with use of electrodes attached to the uterine wall and to the abdominal surface" Get all the results and reference details, order at left...
2.	Endometriosis (Adenomyosis) 12/01/1995 - "A 40 and 50% remission of endometriosis was observed at each location after the administration of 2.0 mg onapristone, whereas 50 and 63% (location A) and 50 and 75% (location B) remissions were found after the administration of 0.4 and 2.0 mg of ZK 136 799 respectively" 12/01/1995 - "These findings may be a further indication of the future potential of antiprogestins such as onapristone and ZK 136 799 in the treatment of endometriosis." 12/01/1995 - "ZK 136 799 was also more potent than onapristone in growth inhibition (85 versus 48% for location B) in animals with persistent endometriosis" 12/01/1995 - "The effects of the progesterone antagonists (antiprogestins) onapristone (ZK 98 299) and ZK 136 799 on surgically induced endometriosis were studied in intact female rats" 12/01/1995 - "Effects of the progesterone antagonists onapristone (ZK 98 299) and ZK 136 799 on surgically induced endometriosis in intact rats." Get all the results and reference details, order at left...
3.	Neoplasms (Cancer) 03/01/1992 - "It was established by morphometric procedures that treatment with Onapristone triggers differentiation of the mitotically active polygonal tumor epithelial cell towards secretory active glandular structures and acini" 04/01/1989 - "Treatment of established MXT(+) tumors with ZK 98.299 (1, 10 and 50 mg/mg) resulted in a strong, dose-dependent inhibition of tumor growth" 01/01/1989 - "Onapristone dramatically blocked tumor growth (% T/C = 7) at the lower dose of MPA; no inhibition (% T/C = 203), however, was detected at the higher dose of MPA" 05/01/1990 - "Treatment of established MXT(+) tumors by ZK 112.993 at doses of 0.5, 1.0 and 2.0 mg/kg led to a strong inhibition that equalled that of ovariectomy and surpassed that of Onapristone in the lower doses" 12/01/1989 - "Antitumor activity of the antiprogestins ZK 98.299 and RU 38.486 in hormone dependent rat and mouse mammary tumors: mechanistic studies." Get all the results and reference details, order at left...
4.	Meningioma (Meningiomas) 03/01/1994 - "In the in vitro arm of the study, mifepristone and onapristone exhibited cytostatic and cytocidal effects against cultured meningioma cells, regardless of the presence or absence of PR's; however, three PR-negative meningiomas showed no response to any dose of mifeprestone and/or onapristone" 03/01/1994 - "The present study examined the antitumor effects of mifepristone and a new potent antiprogesterone agent, onapristone; a correlation between the antitumor effects of these antiprogesterones and the presence of PR's in meningiomas in vitro and in vivo was also investigated" 11/01/1997 - "Growth of meningioma spheroids was quantified in the presence of progesterone and the specific antagonist onapristone" 03/01/1994 - "These findings suggest that mifepristone and onapristone have an antitumor effect against meningioma cells via the PR's and/or another receptor, such as the glucocorticoid receptor." Get all the results and reference details, order at left...
5.	Hemorrhage 04/01/1987 - "This study shows that when administered during the luteal phase ZK 98.299 induces vaginal bleeding and premature luteal regression in bonnet monkeys" 09/01/1995 - "Onapristone (10 mg/kg, s.c.) administered on post-conception days 8-11 caused resorption of implantations and vaginal bleeding in all animals" 04/01/1987 - "On the other hand, in Group II in seven animals with ovulatory treatment cycles, administration of ZK 98.299 induced vaginal bleeding within four days of the first dose and significantly shortened the cycle length" 04/01/1987 - "In Group I animals, administration of ZK 98.299 induced vaginal bleeding in three of the six animals within two days of its first injection" 04/01/1987 - "In two animals of Group II, in which the treatment cycle turned out to be anovulatory, ZK 98.299 did not induce bleeding and had no effect on serum progesterone levels" Get all the results and reference details, order at left...
16 Diseases and 37 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	NG-Nitroarginine Methyl Ester (L-NAME)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Mifepristone (RU 486)
4.	Hormones
5.	Progesterone
6.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
7.	Estrogens (Estrogen)
8.	Tamoxifen
9.	Estrogen Receptor Modulators (Antiestrogen)
10.	Cyproterone Acetate
43 Drugs and Important Bio-Agents and 33 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Orchiectomy (Orchidectomy)
3.	Electrodes (Electrode)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Aftercare (After-Treatment)
5 Therapies and Procedures and 6 more articles analyzed in the Research Interface, order at left...

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