4-hydroxy-N-desmethyltamoxifen

Subscribe to Selected New Research on 4-hydroxy-N-desmethyltamoxifen

8 relevant articles (0 outcomes, 1 trials/studies) found for this Bio-Agent

Description: metabolite of tamoxifen in human bile

Also Known As:

4-hydroxy-N-demethyltamoxifen; 4-hydroxy-N-desmethyltamoxifen, (Z)-isomer; endoxifen

Bio-Agent Context: Research Results

Organic Chemicals: 40

Hydrocarbons: 382

Cyclic Hydrocarbons: 2

Aromatic Hydrocarbons: 115

Benzene Derivatives: 9

Benzylidene Compounds

Stilbenes: 39

Tamoxifen: 7587

4-hydroxy-N-desmethyltamoxifen: 8

Experts

1.	Flockhart, David A: 2 articles (08/2006 - 05/2005)
2.	Lim, Young Chai: 2 articles (08/2006 - 05/2005)
3.	Desta, Zeruesenay: 2 articles (08/2006 - 05/2005)
4.	Skaar, Todd C: 2 articles (08/2006 - 05/2005)
5.	Li, Lang: 1 article (08/2006)
6.	Zhao, Qianqian: 1 article (08/2006)
7.	Rae, James M: 1 article (08/2006)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/2006 - "Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells." 05/01/2005 - "CONCLUSIONS: Since endoxifen is present at greater concentrations than 4-OH-Tam in human plasma of breast cancer patients receiving chronic tamoxifen, these results provide further evidence that endoxifen is as important as, or more important than, 4-OH-Tam to the anti-estrogenic action of tamoxifen." 05/01/2005 - "Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen." 12/01/1989 - "4-Hydroxy-N-desmethyltamoxifen was detected in serum from six out of 10 breast cancer patients receiving 10 mg bid of tamoxifen" 07/01/2006 - "We conducted a prospective trial in 158 patients with breast cancer who were taking tamoxifen to further understand the effect of CYP2D6 genotype and concomitant medications on endoxifen plasma concentrations" Get all the results and reference details, order at left...
2.	Hot Flashes 12/20/2005 - "CONCLUSION: In tamoxifen-treated patients, women with the CYP2D6 4/4 genotype tend to have a higher risk of disease relapse and a lower incidence of hot flashes, which is consistent with our previous observation that CYP2D6 is responsible for the metabolic activation of tamoxifen to endoxifen." Get all the results and reference details, order at left...
2 Diseases and 8 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Tamoxifen
2.	Cytochrome P-450 CYP2D6 (CYP2D6)
3.	4-hydroxytamoxifen
4.	Messenger RNA (mRNA)
5.	Estrogens (Estrogen)
6.	Enzymes
7.	Cytochrome P-450 Enzyme System (Cytochrome P450)
8.	hydroxytamoxifen
8 Drugs and Important Bio-Agents and 8 more articles analyzed in the Research Interface, order at left...

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