|1.||Pastan, Ira: 2 articles (08/2015 - 04/2013)|
|2.||Nordheim, Alfred: 1 article (11/2015)|
|3.||Nagore, Eduardo: 1 article (11/2015)|
|4.||Requena, Celia: 1 article (11/2015)|
|5.||Rachakonda, P Sivaramakrishna: 1 article (11/2015)|
|6.||Guillén, Carlos: 1 article (11/2015)|
|7.||Hosen, Ismail: 1 article (11/2015)|
|8.||Traves, Víctor: 1 article (11/2015)|
|9.||Hemminki, Kari: 1 article (11/2015)|
|10.||Denisova, Evgeniya: 1 article (11/2015)|
|1.||Melanoma (Melanoma, Malignant)
01/01/2012 - "In the present study, we found that diphthamide synthesis 3 (Dph3) is involved in the metastasis of B16F10 murine melanoma cells by insertional mutagenesis. "
01/01/2012 - "Silencing of diphthamide synthesis 3 (Dph3) reduces metastasis of murine melanoma."
11/03/2015 - "Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. "
|2.||Neoplasm Metastasis (Metastasis)
12/01/2014 - "ribosomal frame-shifting, embryonic lethality, neurodegeneration and cancer) typical of mutant cells that cannot make it strongly suggests that diphthamide-modified EF2 occupies an important and translation-related role in cell proliferation and development. "
11/01/2000 - "Down-regulation of the Diphthamide biosynthesis protein 2-like gene during retinoid-induced differentiation and apoptosis: implications against its tumor-suppressor activity."
03/18/2005 - "Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2."
09/01/1998 - "Sequence analysis of the candidate tumor suppressor OVCA1 revealed extensive sequence identity and similarity to proteins from a diverse number of species, including the yeast diphthamide biosynthesis protein-2, dph2, which suggested that OVCA1 may be the human homologue to this yeast gene. "
03/18/2005 - "We demonstrated direct evidence that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2, the target of bacterial ADP-ribosylating toxins. "
09/19/1986 - "In the present experiments, we have analyzed the effects of MeSAdo on diphthamide synthesis in a MeSAdo phosphorylase-deficient mutant murine lymphoma cell line (R1.1, clone H3). "
04/26/2013 - "A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene."
09/19/1986 - "These results suggest that MeSAdo can specifically modulate the biosynthesis of diphthamide in EF-2 in murine malignant lymphoma cells."
09/19/1986 - "Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells."
|5.||Classical Lissencephalies and Subcortical Band Heterotopias
|1.||Peptide Elongation Factor 2 (EF-2)
|4.||Proteins (Proteins, Gene)
|8.||Adenosine Diphosphate (ADP)