Reversed halo sign

A CT scan or chest x-ray imaging feature reminiscent of a halo or an atoll. It is characterized by focal rounded area of ground-glass opacity surrounded by crescent or ring shaped consolidation zone. It is seen in pulmonary diseases, e.g., CRYPTOGENIC ORGANIZING PNEUMONIA and COVID-19.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Pleural Effusion (Pleural Effusions)
2.	Bronchiectasis
3.	Mucormycosis
4.	Tuberous Sclerosis (Bourneville's Disease)
5.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia)

Experts

1.	Fishman, Elliot K: 1 article (01/2021)
2.	Hussein, Amira: 1 article (01/2021)
3.	Lin, Tony: 1 article (01/2021)
4.	Malguria, Nagina: 1 article (01/2021)
5.	Yen, Li-Hsiang: 1 article (01/2021)
6.	Eslambolchi, Azadeh: 1 article (12/2020)
7.	Gholamrezanezhad, Ali: 1 article (12/2020)
8.	Gupta, Amit: 1 article (12/2020)
9.	Maliglig, Ana: 1 article (12/2020)
10.	Basmaciyan, Louise: 1 article (10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Reversed halo sign:

1.	Trimethoprim (Proloprim)FDA LinkGeneric 11/23/2010 - "The patient was diagnosed with pneumocystis pneumonia, which was successfully treated with sulfamethoxazole trimethoprim; the reversed halo sign disappeared, leaving cystic lesions. "
2.	SulfamethoxazoleFDA LinkGeneric 11/23/2010 - "The patient was diagnosed with pneumocystis pneumonia, which was successfully treated with sulfamethoxazole trimethoprim; the reversed halo sign disappeared, leaving cystic lesions. "
3.	SteroidsIBA 05/01/2010 - "In this article, we do not attempt to prove that lung biopsy and steroid treatment are unnecessary in the management of COP, but we would like to propose that, in some situations with the coexistence of a "reversed halo sign" and migratory areas of patchy consolidation on the CT-scan, in the context of a typical clinical presentation and mild symptoms, the usefulness of lung biopsy and steroid treatment is debatable."
4.	Sodium Glutamate (Accent)IBA 10/01/2016 - "Is It Time to Include CT "Reverse Halo Sign" and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients?"
5.	SugarsIBA 12/28/2020 - "Subpleural curvilinear lines, sugar melted sign, intra-lesional vascular enlargement, reverse halo sign, and fibrotic bands were more reported in COVID-19 than H1N1, while air space nodule, tree-in-bud, bronchiectasia, pleural effusion, and cavitation were more seen in H1N1. "
6.	trans-sodium crocetinate (crocetin)IBA 01/01/2013 - "However, a reversed halo sign in TSC has never been reported. " 01/01/2013 - "We describe a reversed halo sign in a teenage girl with tuberous sclerosis complex (TSC). "
7.	4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA 06/01/2015 - "Computed tomography pulmonary angiography (CTPA) may improve the diagnostic capabilities of CT imaging for invasive mold disease, but its performance relative to other signs (ie, halo sign, hypodense sign, pleural effusion, reversed halo sign) is unknown. "
8.	liposomal amphotericin BFDA Link 09/01/2014 - "reversed halo sign on computed tomography scanning, our approach combines liposomal amphotericin B (LAmB) with surgical debridement. "

Therapies and Procedures

1.	Traction 01/01/2022 - "Among pulmonary factors in the hospital, 71.9%, 15.7%,1.7%,19.1% and 53.4% had positive GGO, consolidation, reverse halo sign, traction bronchiectasis and vascular enlargement, respectively. " 01/01/2021 - "Signs of healing and organization include subpleural bands, a reticular pattern, reversed halo sign and traction bronchiectasis. " 01/01/2022 - "Demographic data (age, gender, and known chronic disease) and CT imaging findings (percentage of involvement, number of lesions, distribution preference, dominant pattern, ground-glass opacity distribution pattern, nodule, tree in bud sign, interstitial changes, crazy paving sign, reversed halo sign, vacuolar sign, halo sign, vascular enlargement, linear opacities, traction bronchiectasis, peribronchial wall thickness, air trapping, pleural retraction, pleural effusion, pericardial effusion, cavitation, mediastinal/hilar lymphadenopathy, dominant lesion size, consolidation, subpleural curvilinear opacities, air bronchogram, and pleural thickening) of the patients were evaluated. "
2.	Therapeutics 10/01/2014 - "He began systemic antifungal therapy, underwent computed tomography of the chest demonstrating a large cavitary lesion (reversed halo sign) in the left lung. " 05/01/2012 - "A reversed halo sign may be an early marker to initiate preemptive therapy against Zygomycetes including C. " 06/30/2023 - "This report describes the case of a 38-year-old female who developed progressive aggravation of round-like patchy bilateral pulmonary infiltrated with a reverse halo sign but without any clinical symptoms 5 months after TAM therapy, following breast-conserving surgery and radiotherapy (RT) for breast carcinoma. "
3.	Stem Cell Transplantation 04/01/2014 - "To differentiate mucormycosis from aspergillosis in haematological malignancy and stem cell transplantation recipients, identification of the reverse halo sign on computed tomography is advised with moderate strength. "
4.	Segmental Mastectomy (Lumpectomy) 06/30/2023 - "This report describes the case of a 38-year-old female who developed progressive aggravation of round-like patchy bilateral pulmonary infiltrated with a reverse halo sign but without any clinical symptoms 5 months after TAM therapy, following breast-conserving surgery and radiotherapy (RT) for breast carcinoma. "
5.	Transplantation 05/01/2012 - "elegans) following cord blood transplantation and who showed a reversed halo sign on a chest computed tomography scan (CT). " 05/01/2012 - "Cunninghamella bertholletiae pneumonia showing a reversed halo sign on chest computed tomography scan following cord blood transplantation."