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LGH-447

PIM kinase inhibitor

Also Known As:

LGH 447; LGH447; N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)-3-pyridinyl)-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide; PIM 447; PIM-447

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - LGH-447: 3

Experts

1.	Chu, Emily: 1 article (08/2021)
2.	Kang, Yubin: 1 article (08/2021)
3.	Wu, Jian: 1 article (08/2021)
4.	Kundu, Joydeb Kumar: 1 article (09/2018)
5.	Lee, Mee-Hyun: 1 article (09/2018)
6.	Liu, Zhen-Zhen: 1 article (09/2018)
7.	Song, Mengqiu: 1 article (09/2018)
8.	Zhang, Xinning: 1 article (09/2018)
9.	Beijersbergen, Roderick L: 1 article (01/2018)
10.	Bernards, René: 1 article (01/2018)

Related Diseases

1.	Multiple Myeloma 08/26/2021 - "The inhibition of PIM kinases has become an emerging scientific interest for the treatment of multiple myeloma and several PIM kinase inhibitors, such as SGI-1776, AZD1208, and PIM447 (formerly LGH447), have been developed and are under different phases of clinical trials. " 09/01/2018 - "So far, three kinds of adenosine triphosphate-competitive PIM inhibitors, SGI-1776, AZD1208, and LGH447 have been in clinical trials for the treatment of acute myelogenous leukemia, prostate cancer, lymphoma, or multiple myeloma. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/01/2018 - "So far, three kinds of adenosine triphosphate-competitive PIM inhibitors, SGI-1776, AZD1208, and LGH447 have been in clinical trials for the treatment of acute myelogenous leukemia, prostate cancer, lymphoma, or multiple myeloma. "
3.	Prostatic Neoplasms (Prostate Cancer) 09/01/2018 - "So far, three kinds of adenosine triphosphate-competitive PIM inhibitors, SGI-1776, AZD1208, and LGH447 have been in clinical trials for the treatment of acute myelogenous leukemia, prostate cancer, lymphoma, or multiple myeloma. "
4.	Lymphoma (Lymphomas) 09/01/2018 - "So far, three kinds of adenosine triphosphate-competitive PIM inhibitors, SGI-1776, AZD1208, and LGH447 have been in clinical trials for the treatment of acute myelogenous leukemia, prostate cancer, lymphoma, or multiple myeloma. "
5.	Neuroblastoma 01/01/2018 - "Treatment of neuroblastoma cell lines with the pan-PIM inhibitors AZD1208 or PIM-447 suppressed proliferation through inhibition of mTOR signaling. "

Related Drugs and Biologics

1.	AZD1208
2.	SGI 1776
3.	Phosphotransferases (Kinase)
4.	Adenosine Triphosphate (ATP)
5.	proto-oncogene proteins pim