tris(1,3-dichloroisopropyl) phosphate

01/01/2022 - "Additionally, the aggravated body weight loss and decreased length of TDCIPP offspring were relieved after PA aging. "
11/01/2019 - "Continuous TDCIPP exposure decreased body weight, particularly in 500 mg/kg/day TDCIPP-exposed males, and dose dependently increased the ratio of liver to body weight in both genders. "
05/01/2016 - "There were no significant differences in the body weight, serum thyroxine (T4) and free thyroxine (FT4) levels between the control and TDCIPP treated groups. "
11/01/2015 - "Neither chemical produced changes in maternal body weight or serum thyroid hormones, but relative liver weight was increased at the high doses of both TDCIPP and TCEP. "

06/01/2022 - "Our data demonstrated that the high-throughput screening assay developed in this study was reproducible and could be used to rapidly screen chemicals with liver tumor promoting potentials by using tris-(2-chloropropyl)-phosphate (TDCIPP) as a positive control. "
03/15/2020 - "In this study, Tg(fabp10:rtTA2s-M2; TRE2:EGFP-krasG12V), referred as kras transgenic zebrafish which was shown to be an inducible liver tumor model, was applied as experimental model to assess the promotion potential of TDCIPP for HCC in males. "
03/15/2020 - "Overall, our results suggested that TDCIPP had promotion effect on the progression of liver tumor in kras males."
12/01/2019 - "Collectively, our results suggested that TDCIPP could promote the liver tumor progression by induction of hepatic inflammatory responses."
12/01/2019 - "In this study, krasV12 genetically modified zebrafish, Tg(fabp10:rtTA2s-M2; TRE2:EGFP-krasG12V), a model system in which liver tumors can be induced by doxycycline (DOX), was used to evaluate the liver tumor promotion potential of TDCIPP. "

09/01/2017 - "In the present study, we investigated the cell biological mechanisms of TDCIPP-induced neurotoxicity using undifferentiated human SH-SY5Y neuroblastoma cells as a model. "
01/01/2017 - "In this study, we determined the mechanisms of TDCIPP-induced neurotoxicity in human neuroblastoma (SH-SY5Y) cells. "

12/01/2019 - "Treatment with TDCIPP resulted in increased liver size and caused more aggressive hepatocellular carcinoma (HCC). "
03/15/2020 - "A previous study reported that exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) could promote the progression of hepatocellular carcinoma (HCC) in female HCC model zebrafish. "

11/15/2021 - "The study identifies several nFRs, such as TMPP and EHDPP, TPHP, and TDCIPP, as potential risk factor for NAFLD and advances our understanding of the mechanisms involved, demonstrating the utility of an AOP-based strategy for screening and prioritizing chemicals and elucidating the molecular mechanisms of toxicity."