4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acid

increases cellular ATP production; structure in first source

Also Known As:

mitochonic acid 5; mitochonic acid-5 (MA-5)

Networked: 10 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indoleacetic Acids: 615
        4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid: 10
- Heterocyclic Acids
  - Indoleacetic Acids: 615
    - 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid: 10
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylbutyrates
      - 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid: 10

Experts

1.	Abe, Takaaki: 4 articles (03/2022 - 01/2015)
2.	Suzuki, Chitose: 4 articles (03/2022 - 01/2015)
3.	Suzuki, Takehiro: 4 articles (03/2022 - 01/2015)
4.	Akiyama, Yasutoshi: 3 articles (06/2017 - 01/2015)
5.	Ito, Sadayoshi: 3 articles (06/2017 - 01/2015)
6.	Kikuchi, Koichi: 3 articles (06/2017 - 01/2015)
7.	Kikusato, Motoi: 3 articles (06/2017 - 01/2015)
8.	Kure, Shigeo: 3 articles (06/2017 - 01/2015)
9.	Mano, Nariyasu: 3 articles (06/2017 - 01/2015)
10.	Matsuhashi, Tetsuro: 3 articles (06/2017 - 01/2015)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 08/24/2022 - "Mitochonic Acid 5 (MA-5) enhances mitochondrial ATP production, restores fibroblasts from mitochondrial disease patients and extends the lifespan of the disease model "Mitomouse". " 06/01/2017 - "Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases." 03/01/2022 - "Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. " 12/01/2023 - "A synthesized derivative of this compound, 4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid also called mitochonic acid 5 (MA-5), has shown to increase the survival ratio of fibroblasts from patients with mitochondrial disease under stress-induced conditions. " 01/01/2016 - "Recently, we reported that a newly synthesized indole derivative, mitochonic acid 5 (MA-5), increases cellular ATP level and survival of fibroblasts from patients with mitochondrial disease. "
2.	Parkinson Disease (Parkinson's Disease) 08/24/2022 - "Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model of Caenorhabditis elegans." 01/01/2022 - "Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson's disease model by AMPK-mediated autophagy."
3.	Cardiotoxicity 10/01/2023 - "The mitochonic acid 5 (MA5) shows promise in alleviating mitochondrial dysfunction by promoting mitochondrial ATP synthesis and reducing reactive oxygen species (ROS) accumulation, though its potential in ameliorating DOX-induced cardiotoxicity remains elusive. "
4.	Kidney Diseases (Kidney Disease) 03/01/2022 - "Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. "
5.	Inflammation (Inflammations) 01/01/2022 - "Mitochonic acid 5 promotes the migration of mouse microglial BV‑2 cells in the presence of LPS‑induced inflammation via Mfn2‑associated mitophagy." 01/01/2022 - "A previous study indicated that mitochonic acid 5 (MA‑5) may promote the survival of microglial cells via mitofusin 2 (Mfn2)‑associated mitophagy in response to lipopolysaccharide (LPS)‑induced inflammation. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	indoleacetic acid (indole acetic acid)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	Lipopolysaccharides
6.	4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acid
7.	Plant Growth Regulators (Plant Hormones)
8.	SB 705498
9.	indole
10.	diphenyleneiodonium