diphenyleneiodonium

structure in first source; NADPH oxidase inhibitor

Also Known As:

diphenylene iodonium; diphenyleneiodium chloride; diphenyleneiodonium chloride; diphenyleneiodonium sulfate (2:1); diphenyleneiodonium sulfate (2:1), 125I-labeled; diphenyleneiodonium, 131I-labeled; dibenziodolium

Networked: 149 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Onium Compounds
  - diphenyleneiodonium: 149

Experts

1.	Doroshow, James H: 4 articles (11/2021 - 05/2012)
2.	Lu, Jiamo: 4 articles (11/2021 - 05/2012)
3.	Juhasz, Agnes: 3 articles (10/2016 - 05/2012)
4.	Ko, Seong-Gyu: 2 articles (11/2021 - 11/2021)
5.	Xiao, Rong: 2 articles (01/2019 - 01/2012)
6.	Chopra, Sidharth: 2 articles (11/2017 - 01/2017)
7.	Dasgupta, Arunava: 2 articles (11/2017 - 01/2017)
8.	Karaulia, Pratiksha: 2 articles (11/2017 - 01/2017)
9.	Pandey, Amit Kumar: 2 articles (11/2017 - 01/2017)
10.	Pandey, Manitosh: 2 articles (11/2017 - 01/2017)

Related Diseases

1.	Acute Lung Injury 01/01/2019 - "The aim of this study was to investigate the effects of diphenyleneiodonium (DPI), a NOX inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a rat model. " 01/01/2019 - "Protective effects of diphenyleneiodonium, an NADPH oxidase inhibitor, on lipopolysaccharide-induced acute lung injury."
2.	Dehydration (Water Stress) 06/15/2015 - "Diphenyleneiodonium chloride (DPI), a specific inhibitor of NADPH oxidase, was effective in inhibiting the accumulation of hydrogen peroxide as well as of jasmonates upon dehydration. " 12/01/2002 - "Pretreatment with some ROS scavengers, such as Tiron and dimethylthiourea (DMTU), and an inhibitor of NAD(P)H oxidase, diphenyleneiodonium (DPI), almost completely arrested the increase in ROS and the activities of these antioxidant enzymes induced by water stress or ABA treatment. "
3.	Hypertension (High Blood Pressure) 07/01/2007 - "Other inhibitors, including diphenylene iodonium, aminoethyl benzenesulfono fluoride, S17834, PR39, protein kinase C inhibitors, and VAS2870, have shown promise in vitro, but their in vivo specificity, pharmacokinetics, and effectiveness in hypertension remains to be determined. "
4.	Hypoxia (Hypoxemia) 01/01/1999 - "5. Diphenylene iodonium (DPI; 1 microM) suppressed outward K+ current by approximately 42%, and DPI + hypoxia had no additional effect on the K+ current. " 09/01/1997 - "To investigate mechanisms of inhibition of hypoxic pulmonary vasoconstriction (HPV), we studied pulmonary artery smooth muscle cell (PASMC) responses to hypoxia, utilizing diphenyleneiodonium (DPI), which blocks HPV. " 09/01/1997 - "Pulmonary artery smooth muscle cell [Ca2+]i and contraction: responses to diphenyleneiodonium and hypoxia." 11/15/1995 - "In each case, the response to hypoxia was specifically inhibited by low doses of diphenylene iodonium (Ph1I+). " 01/01/2023 - "Therefore, we used apocynin and another widely-used NOX inhibitor - diphenyleneiodonium (DPI) - to study the role of NOX in ROS homeostasis of hypoxia-tolerant naked mole-rat cortical brain slices during a normoxia➔hypoxia➔reoxygenation protocol. "
5.	Colonic Neoplasms (Colon Cancer) 12/08/2020 - "The aim of our studies was to investigate the influence of low, non-toxic doses of diphenyleneiodonium chloride (DPI), a potent inhibitor of flavoenzymes including NADPH oxidases, on p53-proficient and p53-deficient HCT116 human colon cancer cells and MCF-7 breast cancer cells. " 01/01/2021 - "In this report, we test this hypothesis by treating the HRASG12V-transformed ovarian epithelial cells, mutant KRAS-harboring pancreatic and colon cancer cells of mouse and human origins, as well as cancer xenografts, with diphenyleneiodonium (DPI) and buthionine sulfoximine (BSO) combination, which inhibit NOX activity and glutathione biosynthesis, respectively. " 04/01/2013 - "We found that diphenyleneiodonium (DPI), di-2-thienyliodonium (DTI), and iodonium diphenyl inhibited the growth of Caco2, HT-29, and LS-174T colon cancer cells at concentrations (10-250nM for DPI, 0.5-2.5μM for DTI, and 155nM to 10μM for iodonium diphenyl) substantially lower than needed for DU145 human prostate cancer cells, which do not possess functional NADPH oxidase activity. " 10/31/2010 - "In the present study, we observed that IGF-1 was able to induce ZNF143 expression in HCT116 human colon cancer cells and that wortmannin, an inhibitor of phosphatidylinositide 3- kinase (PI3-kinase), inhibited this induction, as did diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, and monodansylcardavarine (MDC), a receptor internalization inhibitor. " 11/03/2021 - "To evaluate the potential utility of two novel molecules with favorable chemical properties, NSC 740104 and NSC 751140, we compared effects of these compounds to the two standard inhibitors of this class, diphenyleneiodonium and di-2-thienyliodonium, with respect to antiproliferative, cell cycle, and gene expression effects in human colon cancer cells that require the function of NADPH oxidase 1. Both new agents blocked NADPH oxidase-related reactive oxygen production, inhibited tumor cell proliferation, produced a G1/S block in cell cycle progression, and inhibited NADPH oxidase 1 expression at the mRNA and protein levels at low nM concentrations in a fashion similar to or better than the parent molecules. "

Related Drugs and Biologics

1.	NADPH Oxidases (NAD(P)H oxidase)
2.	Lipopolysaccharides
3.	Hydrogen Peroxide (Hydroperoxide)
4.	Protein Kinase C
5.	Fluorides
6.	3- benzyl- 7- (2- benzoxazolyl)thio- 1,2,3- triazolo(4,5- d)pyrimidine
7.	6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one
8.	acetovanillone (apocynin)
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	NADP (NADPH)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Ligation
4.	Subcutaneous Injections