2- (4- hydroxy)- benzoyloxy- 11- hydroxy- 5,7,9(11),13- abietatetraen- 12- one

has antineoplastic activity; isolated from Plectranthus ecklonii; structure in first source

Also Known As:

parvifloron D

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Hydrocarbons: 1726
  - Terpenes: 1531
    - Diterpenes: 1517
      - Abietanes: 44
        2-(4-hydroxy)-benzoyloxy-11-hydroxy-5,7,9(11),13-abietatetraen-12-one: 8
  - Cyclic Hydrocarbons: 96
    - Aromatic Hydrocarbons: 295
      - Polycyclic Aromatic Hydrocarbons: 2081
        Phenanthrenes: 29
        Abietanes: 44
        2-(4-hydroxy)-benzoyloxy-11-hydroxy-5,7,9(11),13-abietatetraen-12-one: 8
Polycyclic Compounds: 7
- Polycyclic Aromatic Hydrocarbons: 2081
  - Phenanthrenes: 29
    - Abietanes: 44
      - 2-(4-hydroxy)-benzoyloxy-11-hydroxy-5,7,9(11),13-abietatetraen-12-one: 8

Experts

1.	Rijo, Patrícia: 6 articles (01/2022 - 01/2016)
2.	Molpeceres, Jesús: 3 articles (11/2019 - 01/2016)
3.	Fernandes, Ana Sofia: 2 articles (01/2020 - 01/2016)
4.	Ntungwe, Epole: 2 articles (01/2020 - 10/2019)
5.	Rijo, Patricia: 2 articles (01/2020 - 10/2015)
6.	Saraiva, Nuno: 2 articles (01/2020 - 01/2016)
7.	Ascensão, Lia: 2 articles (11/2019 - 11/2018)
8.	Eleutério, Carla: 2 articles (11/2019 - 11/2018)
9.	Reis, Catarina Pinto: 2 articles (11/2019 - 01/2016)
10.	Santos-Rebelo, Ana: 2 articles (11/2019 - 11/2018)

Related Diseases

1.	Glioma (Gliomas) 01/01/2020 - "Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P.madagascariensis and P.ecklonii, 6,7-dehydroroyleanone, 7β,6β-dihydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. "
2.	Neoplasms (Cancer) 10/17/2019 - "An identified compound-parvifloron D-was tested in a pair of sensitive and MDR-Multidrug resistance cancer cells (NCI-H460 and NCI-H460/R) and in normal bronchial fibroblasts MRC-5. " 10/15/2015 - "To examine the therapeutic potential of the plant, we evaluated whether parvifloron D displays cytotoxicity against human tumor cells. " 10/15/2015 - "Parvifloron D is a potent cytotoxic compound against several human tumor cells and also a fast and potent apoptotic inducer in leukemia cells." 01/01/2016 - "Parvifloron D is a natural diterpene with a broad and not selective cytotoxicity toward human tumor cells. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 11/04/2018 - "Parvifloron D nanoencapsulation can be considered as a possible efficient alternative approach in the treatment of pancreatic cancer." 11/04/2018 - "Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer." 11/05/2019 - "Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells."
4.	Triple Negative Breast Neoplasms 01/01/2020 - "Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells."
5.	Melanoma (Melanoma, Malignant) 01/01/2016 - "It was shown that Parvifloron D is cytotoxic and can induce, both as free and as encapsulated drug, cell death in melanoma cells (human A375 and mouse B16V5). " 01/01/2016 - "Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy."

Related Drugs and Biologics

1.	Abietanes
2.	6,7-dehydroroyleanone
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	Diterpenes
5.	Albumins

Related Therapies and Procedures

1.	Therapeutics