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Member 1 Subfamily B ATP Binding Cassette Transporter

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Also Known As:
ATP Binding Cassette Transporter, Subfamily B, Member 1; ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1; CD243 Antigen; PGY-1 Protein; 1, P-Glycoprotein; ABCB1, ATP-Dependent Translocase; ATP Dependent Translocase ABCB1; Antigen, CD243; P Glycoprotein; P Glycoprotein 1; PGY 1 Protein; Protein, MDR1B; Translocase ABCB1, ATP-Dependent; ATP-Dependent Translocase ABCB1; MDR1 Protein; MDR1B Protein; Multidrug Resistance Protein 1; P-Glycoprotein; P-Glycoprotein 1
Networked: 6964 relevant articles (218 outcomes, 830 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Efferth, Thomas: 50 articles (07/2022 - 01/2003)
2. Beijnen, Jos H: 45 articles (01/2021 - 04/2004)
3. Ambudkar, Suresh V: 44 articles (05/2022 - 08/2002)
4. Langer, Oliver: 37 articles (01/2022 - 09/2007)
5. Schinkel, Alfred H: 31 articles (01/2021 - 03/2003)
6. Löscher, Wolfgang: 30 articles (01/2022 - 04/2002)
7. Gottesman, Michael M: 28 articles (11/2020 - 06/2003)
8. Chen, Zhe-Sheng: 27 articles (01/2022 - 04/2007)
9. Molnár, Joseph: 27 articles (11/2018 - 01/2002)
10. Riganti, Chiara: 26 articles (01/2022 - 11/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Alzheimer Disease (Alzheimer's Disease)
4. Carcinoma (Carcinomatosis)
5. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Doxorubicin (Adriamycin)
3. ATP-Binding Cassette Transporters (ABC Transporters)
4. Paclitaxel (Taxol)
5. Adenosine Triphosphate (ATP)
6. multidrug resistance-associated protein 1
7. Monoclonal Antibodies
8. Xenobiotics
9. Amyloid (Amyloid Fibrils)
10. Peptides (Polypeptides)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Intravenous Administration
4. Combination Drug Therapy (Combination Chemotherapy)
5. Castration