Immunity of the Croatian population to poliomyelitis--a serosurvey.

Abstract

Eight years after the last case of poliomyelitis it was of a special interest to determine the immunity level of the Croatian population to polio and thus to evaluate the possible risk of the revival of this infection. For this purpose, 200 sera samples were collected from individuals of different age and place of residence. Neutralizing antibodies (NT) for all three polioviruses were searched for. Antibody titers of > or = 1:8 were considered positive. Results of the study showed some 75% of the study subjects to have antibodies to polio type 1 and 2, and some 83% to type 3. Only 4% of the sera tested had no NT antibodies to any of the three types. The lowest mean geometric antibody titer (GMT) was for polio type 3 (GMT3 = 19.4; reciprocal value) and somewhat higher for type 1 (GMT1 = 23.5) and type 2 (GMT2 = 22.6). When the antibody titers were related with the age of the subjects, they were found not to decline with age, which was ascribed to periodical boosters with vaccinal strains. It is stressed that, in spite of the eradication of poliomyelitis achieved in Croatia, compulsory vaccination of the children should be continued until its global eradication.

• Authors: B Borcić, V Kruzić, B Kaić, S Ljubin-Sternak, M Ljubicić, V Dobrovsak-Sourek
• Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti (Acta Med Croatica) Vol. 52 Issue 4-5 Pg. 229-33 ( 1998) ISSN: 1330-0164 [Print] Croatia
• PMID: 9988903 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral

Topics

• Adolescent
• Adult
• Antibodies, Viral (analysis)
• Child
• Croatia
• Humans
• Immunity
• Middle Aged
• Poliomyelitis (immunology, prevention & control)
• Poliovirus (immunology)
• Vaccination