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The effect of difenoxin on the lower esophageal sphincter pressure in man.

Abstract
Difenoxin, a new antidiarrheal agent, had no effect on lower esophageal sphincter pressure in man when given at an oral dose of 2 mg. Thus, this drug does not appear to cause or aggravate symptoms of gastro-esophageal reflux and may safely be used in reflux patients.
AuthorsB A Bron, G J Krejs, P Peter, A L Blum
JournalArchives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 222 Issue 1 Pg. 40-4 (Jul 1976) ISSN: 0003-9780 [Print] Belgium
PMID984970 (Publication Type: Journal Article)
Chemical References
  • Antidiarrheals
  • Isonipecotic Acids
  • Placebos
  • Diphenoxylate
Topics
  • Antidiarrheals (pharmacology)
  • Diphenoxylate (analogs & derivatives, pharmacology)
  • Esophagogastric Junction (drug effects)
  • Female
  • Humans
  • Isonipecotic Acids (pharmacology)
  • Male
  • Manometry
  • Placebos
  • Pressure
  • Time Factors

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