Spermatozoa with chromosomal abnormalities may result in a higher rate of recurrent abortion.

Abstract

OBJECTIVE:

To determine whether sperm aneuploidy can lead to abortion.

DESIGN:

Clinical study.

SETTING:

Couples with reproductive problems evaluated in a private diagnostic laboratory.

PATIENT(S):

Two men whose wives had histories of multiple abortions.

INTERVENTION(S):

Whole and Percoll-processed semen samples were analyzed.

MAIN OUTCOME MEASURE(S):

The results of fluorescence in situ hybridization.

RESULT(S):

Aneuploidy rates in Percoll-processed samples were higher than those found in whole specimens. Aneuploid spermatozoa also displayed greater motility.

CONCLUSION(S):

Sperm aneuploidy should be studied before and after Percoll capacitation in all couples with unexplained infertility.

• Authors: C Giorlandino, G Calugi, L Iaconianni, M L Santoro, A Lippa
• Journal: Fertility and sterility (Fertil Steril) Vol. 70 Issue 3 Pg. 576-7 (Sep 1998) ISSN: 0015-0282 [Print] United States
• PMID: 9757896 (Publication Type: Case Reports, Journal Article)

Topics

• Abortion, Habitual (genetics)
• Adult
• Aneuploidy
• Chromosome Aberrations
• Chromosome Disorders
• Female
• Humans
• In Situ Hybridization, Fluorescence
• Male
• Pregnancy
• Spermatozoa (physiology)