Effect of triamcinolone on the ultrastructure of mouse hepatocytes.

Premature female mice were injected daily with 1.5 mg/kg body weight of triamcinolone diacetate for 10 and 21 consecutive days. Electron-microscopic study of hepatocytes indicated the formation of 'giant' mitochondria concomitant with a marked increase in the number and size of lipid droplets. Hypertrophied mitochondria and enlarged lipid droplets were found to be in a close topographical association. The mechanism of mitochondrial enlargement is discussed as well as the latters' role in the hepatocytes' lipid metabolism.
AuthorsR Ludatscher, M Silbermann
JournalActa anatomica (Acta Anat (Basel)) Vol. 96 Issue 2 Pg. 176-87 ( 1976) ISSN: 0001-5180 [Print] Switzerland
PMID970101 (Publication Type: Journal Article)
Chemical References
  • Triamcinolone
  • Animals
  • Cytoplasm (metabolism, ultrastructure)
  • Female
  • Lipid Metabolism
  • Liver (drug effects, ultrastructure)
  • Mice
  • Mitochondria, Liver (drug effects, ultrastructure)
  • Triamcinolone (pharmacology)

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