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Nitidon, a new bioactive metabolite from the basidiomycete Junghuhnia nitida (Pers.: Fr.) Ryv.

Abstract
Nitidon, a highly oxidised pyranone derivative produced by the basidiomycete Junghuhnia nitida, has been isolated and its biological activities evaluated. The structure was determined by spectroscopic methods. Nitidon exhibits antibiotic and cytotoxic activities and induces morphological and physiological differentiation of tumor cells at nanomolar concentrations.
AuthorsA Gehrt, G Erkel, T Anke, O Sterner
JournalZeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 1998 Jan-Feb Vol. 53 Issue 1-2 Pg. 89-92 ISSN: 0939-5075 [Print] Germany
PMID9528126 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkynes
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Epoxy Compounds
  • nitidon
Topics
  • Alkynes (chemistry, isolation & purification, pharmacology)
  • Animals
  • Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Basidiomycota (chemistry)
  • Cell Differentiation (drug effects)
  • Cell Line
  • Cricetinae
  • Epoxy Compounds (chemistry, isolation & purification, pharmacology)
  • HL-60 Cells
  • Humans
  • Leukemia L1210 (pathology)
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure

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