Abstract | OBJECTIVE: METHODS: RESULTS: Patients with primary systemic vasculitis generated significantly more superoxide than all 3 non- vasculitis groups. Superoxide generation in the autoimmune vasculitis group was also higher than other groups but failed to reach significance versus controls (p = 0.07). Generation of MPO dependent products was also significantly higher in patients with primary vasculitis compared to all other groups. Subgroup analysis within the primary vasculitis group showed no correlation of these findings with disease activity, antineutrophil cytoplasmic antibodies, or American College of Rheumatology classification. CONCLUSION:
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Authors | I Bruce, J McNally, A Bell |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 24
Issue 12
Pg. 2364-70
(Dec 1997)
ISSN: 0315-162X [Print] Canada |
PMID | 9415643
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Reactive Oxygen Species
- Peroxidase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
(blood)
- Autoimmune Diseases
(immunology, metabolism, pathology)
- Female
- Humans
- Male
- Middle Aged
- Monocytes
(enzymology, immunology)
- Necrosis
- Peroxidase
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Respiratory Burst
- Vasculitis
(immunology, metabolism, pathology)
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