Abstract |
The excretion of ketobemidone into human breast milk was investigated in three women who obtained ketobemidone as postoperative pain relief after Cesarean section and two women premedicated with 5 mg of ketobemidone before currettage after delivery. The highest observed concentration of ketobemidone in breast milk was 36 ng/ml three hours after administration, and 4-7 hours after administration the concentration was 3-5 fold that in maternal plasma. It could be estimated that the newborn will be exposed to less than 2 micrograms of ketobemidone during the first 24 hours.
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Authors | E Gerdin, U Bondesson, P Hartvig |
Journal | Journal of perinatal medicine
(J Perinat Med)
Vol. 24
Issue 3
Pg. 293-5
( 1996)
ISSN: 0300-5577 [Print] Germany |
PMID | 8827580
(Publication Type: Journal Article)
|
Chemical References |
- Analgesics, Opioid
- Meperidine
- ketobemidone
|
Topics |
- Analgesics, Opioid
(analysis, blood, pharmacokinetics)
- Cesarean Section
- Drug Residues
(analysis)
- Female
- Humans
- Meperidine
(analogs & derivatives, analysis, blood, pharmacokinetics)
- Milk, Human
(chemistry, metabolism)
- Pain, Postoperative
(drug therapy)
- Pregnancy
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