Gastrin levels in mothers and neonates at delivery in various perinatal conditions.

Abstract

BACKGROUND:

This study was designed to assess the variations of gastrin (Ga) serum levels in mothers and newborns at birth in some perinatal disorders.

MATERIALS AND METHODS:

Ga levels were measured by RIA in maternal serum, amniotic fluid and cord sera of newborns in 55 cases with the following conditions: normal pregnancy and eutocic vaginal delivery (n = 8), repeat cesarean section (n = 10), and cardiotogographic register suggestive of fetal compromise (n = 15), cephalopelvic disproportion (n = 8), preeclampsia (n = 7) and postdate pregnancy (n = 7). Statistical analysis was performed by Mann-Whitney U test.

RESULTS:

Ga levels in cord sera of newborn and amniotic fluid in normal pregnancy and eutocic delivery were significantly higher (p < 0.02 and p < 0.01, respectively) than those found in patients with repeat cesarean operation. Serum Ga concentrations in women with postterm pregnancy were significantly higher (p < 0.02) than in women with prior cesarean section. Ga levels in amniotic fluid samples in the presence of suspected fetal compromise and postdate pregnancy were significantly higher (p < 0.001) than those observed in women who had repeat cesarean operation.

CONCLUSION:

Vaginal delivery and perinatal pathology may induce hypergastrinemia in both mother and neonate at birth.

• Authors: C Morán, S Carranza-Lira, R Ochoa, J C Martínez, M Herrera, E Fonseca, A Zárate
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 75 Issue 7 Pg. 608-11 (Aug 1996) ISSN: 0001-6349 [Print] United States
• PMID: 8822651 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrins

Topics

• Adult
• Amniotic Fluid (chemistry)
• Cesarean Section
• Delivery, Obstetric
• Female
• Fetal Blood (chemistry)
• Gastrins (analysis, blood)
• Humans
• Infant, Newborn
• Labor Presentation
• Pregnancy