The combined assessment of cellular apoptosis, mitochondrial function and proliferative response to pokeweed mitogen has prognostic value in SIV infection.

Abstract

Using the assessment of the mitochondrial metabolic activity of freshly isolated blood mononuclear cells, the flow cytometric detection of apoptosis and of the proliferative responses to PWM, SIV-infected macaques were classified in: stage 0, which included all animals with unaffected parameters, and stages 1, 2, and 3, which included animals having one, two, or all three parameters affected, respectively. This novel three-parametric staging system (ISS) provides a new prognostic tool in the longitudinal study of SIV infection.

• Authors: A M del Llano, J P Amieiro-Puig, E N Kraiselburd, M J Kessler, C A Málaga, J A Lavergne
• Journal: Journal of medical primatology (J Med Primatol) 1993 Feb-May Vol. 22 Issue 2-3 Pg. 147-53 ISSN: 0047-2565 [Print] Denmark
• PMID: 8411106 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pokeweed Mitogens

Topics

• Animals
• Apoptosis
• HIV Infections (immunology, metabolism, pathology)
• Humans
• In Vitro Techniques
• Lymphocyte Activation
• Macaca mulatta
• Mitochondria (metabolism)
• Pokeweed Mitogens (pharmacology)
• Prognosis
• Simian Acquired Immunodeficiency Syndrome (immunology, metabolism, pathology)
• Time Factors