[Indices of left heart ventricle relaxation after 5-months of hypotensive therapy with guanfacine].

Abstract

The subject of the work is to assess the clinical parameters and diastolic function in patients with mild or moderate essential hypertension after 5-month treatment with guanfacine 0.5-3 mg/day, mean 1.7 mg. In the group there were 8 women and 8 men, mean age 53.7 +/- 7.6. The diastolic function of the left ventricle was assessed from the echocardiographic M-mode paper sweep of the left ventricle by the method of Gibson and Brown. In clinical parameters systolic, diastolic and mean blood pressure was found to decrease significantly, the heart rate was unchanged. Essential improvement of the markers of relaxation was received while amelioration of filling was not significant. The before treatment data were compared with the similar ones of the 60 persons of the control group. The significant differences were found in values of blood pressure, markers of relaxation and indices Iv and Ip.

• Authors: A Kubasik, A Rynkiewicz, J Jaromczyk-Slisz, H Jasiel-Wojculewicz, B Krupa-Wojciechowska
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) 1993 Jan 4-11 Vol. 48 Issue 1-2 Pg. 15-8 ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Wskaźniki rozkurczu lewej komory serca po 5 miesiacach terapii hipotensyjnej guanfacyna.
• PMID: 8361874 (Publication Type: Journal Article)

Chemical References

• Guanfacine

Topics

• Diabetes Mellitus, Type 2 (drug therapy)
• Diabetic Angiopathies (diagnostic imaging, drug therapy)
• Diastole (physiology)
• Echocardiography
• Female
• Guanfacine (therapeutic use)
• Humans
• Hypertension (diagnostic imaging, drug therapy)
• Hypotension (drug therapy, physiopathology)
• Male
• Middle Aged
• Ventricular Function, Left (drug effects)