Protective role of vanadium in the survival of hosts during the growth of a transplantable murine lymphoma and its profound effects on the rates and patterns of biotransformation.

Abstract	Vanadium, as ammonium mononium monovanadate, has been found to have anticarcinogenic effect in host mice bearing a transplantable ascitic lymphoma. The potentiating effect of vanadium was supported by biochemical analysis of autopsies relating to markers like microsomal cytochrome P-450, UDP glucuronyl transferase (UDPGT) and cytosolic glutathione-S-transferase (GSHT) in the hepatic tissue of the hosts, which showed substantial alterations in the extent of tumor regression as compared to their lymphoma and normal counterparts, prolonging the survival of the hosts.
Authors	S Sardar, R Ghosh, A Mondal, M Chatterjee
Journal	Neoplasma (Neoplasma) Vol. 40 Issue 1 Pg. 27-30 ( 1993) ISSN: 0028-2685 [Print] Slovakia
PMID	8350944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Vanadium Cytochrome P-450 Enzyme System Glucuronosyltransferase Glutathione Transferase
Topics	Animals Biotransformation Cytochrome P-450 Enzyme System (biosynthesis) Dose-Response Relationship, Drug Glucuronosyltransferase (biosynthesis) Glutathione Transferase (biosynthesis) Liver (metabolism) Lymphoma (drug therapy, enzymology) Male Mice Mice, Inbred Strains Microsomes, Liver (enzymology) Neoplasm Transplantation Vanadium (pharmacokinetics, pharmacology, therapeutic use)

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