Detection of endotoxins with the Limulus test in burned and unburned mice infected with different species of gram-negative bacteria.

Abstract	The Limulus test detected endotoxins in the plasma of burned and unburned mice infected with different species of gram-negative bacteria produced different amounts of endotoxin in the plasma of infected mice. Plasma from mice given lethal infections showed very high concentrations of endotoxin. Low concentrations of endotoxin in the plasma were tolerated by mice but high concentrations were invariably fatal. A polyvalent pseudomonas vaccine reduced endotoxin in the plasma of mice given lethal infections of Pseudomonas aeruginosa.
Authors	R J Jones, E A Roe, R E Dyster
Journal	The Journal of hygiene (J Hyg (Lond)) Vol. 75 Issue 1 Pg. 99-112 (Aug 1975) ISSN: 0022-1724 [Print] England
PMID	807621 (Publication Type: Journal Article)
Chemical References	Bacterial Vaccines Endotoxins
Topics	Administration, Topical Animals Arachnida Bacteria Bacterial Infections (diagnosis) Bacterial Vaccines Biological Assay Burns (blood, complications, microbiology) Endotoxins (blood) Injections, Intraperitoneal Male Mice Mice, Inbred Strains Proteus mirabilis Pseudomonas aeruginosa Sepsis (diagnosis) Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!