Serum immunosuppressive acid protein predicts lymph node metastases in patients with renal cell carcinoma.

Abstract

OBJECTIVE:

To evaluate the usefulness of serum immunosuppressive acid protein (IAP) as a marker for lymph node metastases in patients with renal cell carcinoma.

PATIENTS AND METHODS:

Serum IAP levels were studied in 73 patients with renal cell carcinoma, prior to therapy. Serum IAP levels were correlated with the clinical and the post-operative histopathological stage. A threshold value of 800 micrograms/ml was applied.

RESULTS:

Statistical analysis revealed a better correlation between IAP concentration and disease than with any other variable. Sensitivity and specificity were 94% and 84%, respectively, thus providing good positive (65%) and negative (98%) predictive values regarding lymph node involvement.

CONCLUSION:

Measuring serum IAP levels can be a valuable contribution to lymph node staging in patients with renal cell cancer. The choice of cut-off value of 800 micrograms/ml has yet to be supported by a larger series.

• Authors: K Pummer, P Pürstner, H L Auner, H Stettner, H Trummer, H Penkoff, M Rauchenwald
• Journal: British journal of urology (Br J Urol) Vol. 73 Issue 6 Pg. 612-4 (Jun 1994) ISSN: 0007-1331 [Print] England
• PMID: 8032825 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Neoplasm Proteins
• immunosuppressive acidic protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Carcinoma, Renal Cell (blood, pathology, secondary)
• Female
• Humans
• Kidney Neoplasms (blood, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Proteins (blood)
• Neoplasm Staging