[Clinical study of the effectiveness of a new preservative-free polyvidon preparation in therapy of dry-eye disorders].

Abstract

BACKGROUND:

Diseases of the ocular surface very frequently seen are related to irregularities of wetting. Patients often have complaints and feeling of ill-health, although under symptomatic therapy. Tolerability of the tear substitutes plays a key role in these cases. It is improved with unpreserved medication.

METHOD:

59 patients with 'dry eye condition' of various etiology were enrolled in an open multicentre study and treated 8 weeks with a new preservative-free tear substitute. All patients had a history of previous ineffective treatment with artificial tears. The product was formulated with polyvidone and electrolytes in a composition which resembles natural tears. The therapeutic effect was evaluated by ratings of patients' self assessment of their complaints, tear film break up time (BUT), Schirmer I test, visual acuity, biomicroscopic examination and physicians' assessment.

RESULTS:

Based on the key criteria patients's self assessment and BUT, the new agent (Oculotect fluid sine) improved symptoms and reduced discomfort significantly compared with the previous treatment (paired t test, two-sided, level of significance p < or = 0.05). The improved condition was confirmed by the other findings taken.

CONCLUSION:

In 4/5 of patients, as typically met in ophthalmologists' offices, whose complaints were insufficiently relieved by previously applied tear substitutes, treatment with the new preservative-free product resulted in a distinct improvement of their condition. The lack of preservatives contributed to better tolerability and acceptance of tear substitution.

• Authors: H Mayer, C Feuerhake, P Joost, U Sander
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 205 Issue 3 Pg. 138-42 (Sep 1994) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Klinische Studie zur Wirksamkeit eines neuen unkonservierten Polyvidon-Präparats zur Therapie von Benetzungsstörungen.
• PMID: 7996818 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Electrolytes
• Ophthalmic Solutions
• Povidone

Topics

• Adult
• Aged
• Aged, 80 and over
• Dry Eye Syndromes (etiology, therapy)
• Electrolytes (administration & dosage)
• Female
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Povidone (administration & dosage, adverse effects)
• Tears (metabolism)
• Visual Acuity (drug effects)