Plasma potassium changes following suxamethonium and suxethonium in normal patients and in patients in renal failure.

Abstract

Fifty-four healthy patients and 21 patients with chronic renal disease received either suxamethonium 100 mg or suxethonium 150 mg for neuromuscular blockade during endotracheal intubation. A significant increase in plasma potassium concentration was observed following the administration of suxamethonium. No increase occurred in patients who received suxethonium. It is concluded that suxethonium may be preferable to suxamethonium in patients who are at risk from an increase in the plasma potassium concentration.

• Authors: S Day
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 48 Issue 10 Pg. 1011-5 (Oct 1976) ISSN: 0007-0912 [Print] England
• PMID: 791307 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Neuromuscular Depolarizing Agents
• Succinylcholine
• suxethonium
• Potassium

Topics

• Adult
• Clinical Trials as Topic
• Female
• Humans
• Kidney Failure, Chronic (blood)
• Male
• Neuromuscular Depolarizing Agents (pharmacology)
• Potassium (blood)
• Renal Dialysis
• Succinylcholine (analogs & derivatives, pharmacology)
• Time Factors