Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs.

Abstract

The effect of a 30-min infusion of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydroseselin (Pd-Ia), a coumarin isolated from Peucedanum praeruptorum Dunn 0.15 mg.kg-1.min-1 on regional myocardial dysfunction was examined in 16 anesthetized open-chest dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. Segment lengths of left ventricular wall were measured with an ultrasonic micrometer. The control caused a decrease in the % of segment shortening (SS%) throughout the reperfusion period (n = 8), while Pd-Ia ameliorated segment function immediately after reperfusion and restored the SS% to 41 +/- 51% of the baseline value (n = 8, P < 0.05 vs control) 5 min after reperfusion without any significant changes in cardiohemodynamics. The improvement of myocardial function induced by Pd-Ia was maintained at least 3 h after reperfusion. These findings revealed that Pd-Ia had a cardioprotective action in stunned myocardium.

• Authors: T H Chang, H Adachi, T Okuyama, K Y Zhang
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 15 Issue 5 Pg. 388-91 (Sep 1994) ISSN: 0253-9756 [Print] China
• PMID: 7717058 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Coumarins
• Drugs, Chinese Herbal
• 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin

Topics

• Animals
• Calcium Channel Blockers (isolation & purification, therapeutic use)
• Coumarins (isolation & purification, therapeutic use)
• Dogs
• Drugs, Chinese Herbal (chemistry)
• Female
• Male
• Myocardial Contraction (drug effects)
• Myocardial Reperfusion Injury (prevention & control)
• Myocardial Stunning (prevention & control)