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Liposomal amphotericin B therapy of murine histoplasmosis.

Abstract
Liposomal amphotericin B (AmBisome) was compared with amphotericin B deoxycholate for the treatment of disseminated murine histoplasmosis. Liposomal amphotericin B was well tolerated and, milligram for milligram, was as potent as amphotericin B deoxycholate.
AuthorsJ R Graybill, R Bocanegra
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 39 Issue 8 Pg. 1885-7 (Aug 1995) ISSN: 0066-4804 [Print] United States
PMID7486941 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antifungal Agents
  • Drug Carriers
  • Liposomes
  • Amphotericin B
Topics
  • Amphotericin B (administration & dosage, therapeutic use)
  • Animals
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Colony Count, Microbial
  • Drug Carriers
  • Histoplasmosis (drug therapy, microbiology)
  • Immunosuppression Therapy
  • Kidney (microbiology)
  • Liposomes
  • Mice
  • Mice, Inbred BALB C
  • Spleen (microbiology)

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