[Effects of gamma-oryzanol on the movements of stomach and ileum in the dog (author's transl)].

Abstract

Gastric and ileal movements were measured after administration of gamma-Oryzanol in the dog. 1. Gastric and ileal movement were enhanced after intravenous administration of 1 mg/kg body weight of gamma-Oryzanol. The higher dose of gamma-Oryzanol produced the shorter latency of these enhanced movements and thereafter, induced the inhibition of these movements. 2. When bilateral vagal nerves and the splanchnic nerves were previously transected or administered atropine, no enhancement of the gastric and ileal movement were observed by administration of gamma-Oryzanol. Furthermore, these enhanced movement produced with gamma-Oryzanol were abolished by atropine injection during these enhanced movement. 3. The inhibitory movement of the stomach and the ileum produced by administration of gamma-Oryzanol of 10 mg/kg body weight were reversely existed by the transection of vagal nerves in the cervical region or by administration of quinidine. These results indicate that gamma-Oryzanol produces the enhancement as well as inhibition of gastric and ileal movements. These effects may be produced by reaction to the central nervous system of the gastric and ileal movements.

• Authors: T Mizonishi, T Semba
• Journal: Nihon Heikatsukin Gakkai zasshi (Nihon Heikatsukin Gakkai Zasshi) Vol. 16 Issue 1 Pg. 47-55 (Mar 1980) ISSN: 0374-3527 [Print] Japan
• PMID: 7277932 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phenylpropionates
• Atropine
• gamma-oryzanol

Topics

• Animals
• Atropine (pharmacology)
• Dogs
• Gastrointestinal Motility (drug effects)
• Ileum (physiology)
• Phenylpropionates (pharmacology)
• Stomach (physiology)