[Duodenal ulcer - multicenter double-blind study with proglumide].
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| Abstract |
In a randomised multicenter double blind study we investigated the healing-rate with proglumid and an antacid drug, studying 70 in- and outpatients with florid duodenal ulcer. We evaluated the size and depth of 59 chronic duodenal ulcers in 52 patients with endoscopic and x-ray-investigations before and after four-week-treatment. Inpatients of the proglumid-group had a significant higher healing-rate than inpatients in the antacid-group (95% against 70%, p less than 0.05). As found in endoscopy the outpatients in the proglumid-group had a higher healing-rate, but because of the smaller number of patients the difference was not significant. Summarized the in- and outpatients, the proglumid-group had a healing-rate of 83%, the antacid-group of 60% (p less than 0.05). Bigger ulcers with a size more than 120 mm2 at the beginning showed a significant better healing with proglumid than with the antacid-drug (t/2 = 14.6 resp. 24.6 days). With x-ray-examination we could not find differences of healing between the two groups, but younger patients often were not examined. The symptoms of patients did not show a significant difference during the healing-course. We could not find any side-effects. Proglumid is an effective drug for the healing of chronic duodenal ulcers.
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| Authors | W Bergemann, K Consentius, H E Braun, H Hirschmann, B Marowski, A Munck, H U Rehs, D Stopik, G Wilke |
| Journal | Medizinische Klinik (Med Klin) Vol. 76 Issue 8 Pg. 226-9 (Apr 10 1981) ISSN: 0025-8458 [Print] Germany |
| Vernacular Title | Ulcera duodeni - multizentrische Doppelblind-Studie mit Proglumid. |
| PMID | 7231338 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial) |
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