Hemodynamic effects of single-dose administration of AR-L 115 BS in patients with coronary artery disease.

Abstract

2-[(2-Methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) was investigated in 14 patients with coronary artery disease (CAD) and an elevated left ventricular enddiastolic pressure at rest (LVEDP). There was a significant decrease in the systolic (AOPS) and diastolic aortic pressures (AOPD) of 9% and 6%, respectively, (p less than 0.001, p less than 0.01). The LVEDP decreased by 29% (p less than 0.001), and the maximum rate of pressure rise (dp/dt max) increased by 19% (p less 0.001). The systolic (PAPS) and diastolic pulmonary artery pressures (PAPD) fell by 17% and 16%, respectively (p less than 0.05). The cardiac index (CI) increased by 12% (p less than 0.05), and the peripheral resistance (SVR) fell by 17% (p less than 0.001). Heart rate increased slightly by 5% (p less than 0.1) but this was of no clinical relevance. The right atrial pressure (RAP) and the tension time index (TTI) remained unchanged. AR-L 15 BS was observed to have vasodilating and positive inotropic effects without increasing oxygen consumption. It can therefore be recommended for use in patients with CAD and an elevated LVEDP. Side-effects have not been reported.

• Authors: A Weikl, S Kohlschütter, O E Durst, E Lang
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 1a Pg. 244-7 ( 1981) ISSN: 0004-4172 [Print] Germany
• PMID: 7195232 (Publication Type: Journal Article)

Chemical References

• Cardiotonic Agents
• Imidazoles
• sulmazole

Topics

• Adult
• Blood Pressure (drug effects)
• Cardiac Catheterization
• Cardiac Output (drug effects)
• Cardiotonic Agents (pharmacology)
• Coronary Disease (physiopathology)
• Electrocardiography
• Female
• Hemodynamics (drug effects)
• Humans
• Imidazoles (pharmacology)
• Male
• Middle Aged
• Time Factors