[Concentration of dibekacin sulfate in bone (author's transl)].

Abstract	The concentrations in serum, cancellous and cortical bones of dibekacin sulfate were measured in 16 cases. Dibekacin sulfate rapidly penetrates into bone. The peak concentration in serum and cancellous bone is reached within 1 hour after intramuscular injection and the concentration in cancellous bone parallels that in serum. The concentration in cortical bone increases with time. Cancellous bone has higher concentration than cortical bone. Dibekacin sulfate is suitable for prevention of infection in orthopaedic surgery, because it maintains a bactericidal level in bone for enough time.
Authors	S Kikuchi, I Hoshika, T Matsui, M Hasue
Journal	The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 35 Issue 3 Pg. 779-83 (Mar 1982) ISSN: 0368-2781 [Print] Japan
PMID	7097980 (Publication Type: English Abstract, Journal Article)
Chemical References	Anti-Bacterial Agents Dibekacin Kanamycin
Topics	Adult Aged Anti-Bacterial Agents (blood, metabolism) Bone and Bones (metabolism, surgery) Dibekacin (blood, metabolism) Female Humans Injections, Intramuscular Kanamycin (analogs & derivatives) Kinetics Male Middle Aged Models, Biological Premedication Time Factors

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