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Treatment of hyperlactacidemia in cirrhotic patients with pyridoxine-alpha-ketoglutarate (PAK).

Abstract
After pyridoxine-alpha-ketoglutarate (PAK) was administered to patients with hepatic cirrhosis, the blood level values for lactic acid and ammonia showed a statistically significant reduction. These results suggest that PAK can be used for treatment adn prevention of hyperlactacidemia secondary to chronic hepatopathy.
AuthorsA Belvisi, M Matergi, F Fici
JournalInternational journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 20 Issue 3 Pg. 142-6 (Mar 1982) ISSN: 0174-4879 [Print] Germany
PMID7068288 (Publication Type: Journal Article)
Chemical References
  • Lactates
  • conductase
  • Lactic Acid
  • Ammonia
  • Pyridoxine
Topics
  • Acidosis (drug therapy)
  • Adult
  • Aged
  • Ammonia (blood)
  • Double-Blind Method
  • Female
  • Humans
  • Lactates (blood)
  • Lactic Acid
  • Liver Cirrhosis (blood)
  • Male
  • Middle Aged
  • Pyridoxine (analogs & derivatives, therapeutic use)

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