Functional alterations in non-T cells in rheumatic heart disease.

Abstract

The mediation of the T cell lymphoproliferative response to streptococcal blastogen A by non-T mononuclear cells was studied in patients with rheumatic heart disease (RHD) and control subjects. Non-T cells are essential for T cell response to blastogen A. Non-T cells from RHD patients were less effective in enabling the T lymphocyte response to blastogen A than control non-T cells though no consistent difference was observed in the response to phytohaemagglutinin. The results suggest that a functional alteration is present in the non-T cells from RHD patients which might be related to the pathogenesis of the disease.

• Authors: E D Gray, W E Regelmann, L W Wannamaker, A El Kholy, Z H Abdin
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 49 Issue 2 Pg. 488-92 (Aug 1982) ISSN: 0009-9104 [Print] England
• PMID: 6982139 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Bacterial Proteins
• Mitogens
• streptococcal group A mitogen

Topics

• Bacterial Proteins
• Humans
• Lymphocyte Activation
• Lymphocytes (immunology)
• Mitogens (immunology)
• Palatine Tonsil (immunology)
• Rheumatic Heart Disease (immunology)
• Rosette Formation
• T-Lymphocytes (immunology)