New anthracycline glycosides from Micromonospora. II. isolation, characterization and biological properties.

Abstract	Four glycosides, designated A, B, C and D, are the main components of the anthracycline complex produced by cultures of Micromonospora sp. nov. They were extracted by solvent partition, separated by column chromatography and characterized by chemical and physical methods as 11-deoxy analogues of daunorubicin. Among these new anthracyclines, displaying antibacterial and cytotoxic activity in vitro, 11-deoxydaunorubicin and 11-deoxydoxorubicin are also active against P388 leukemia in mice.
Authors	G Cassinelli, F Di Matteo, S Forenza, M C Ripamonti, G Rivola, F Arcamone, A Di Marco, A M Casazza, C Soranzo, G Pratesi
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 33 Issue 12 Pg. 1468-73 (Dec 1980) ISSN: 0021-8820 [Print] England
PMID	6941955 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic Glycosides Naphthacenes
Topics	Animals Antibiotics, Antineoplastic Bacteria (drug effects) Cell Survival (drug effects) Cells, Cultured Chemical Phenomena Chemistry Chemistry, Physical Drug Resistance, Microbial Glycosides (biosynthesis, isolation & purification, pharmacology) Humans Lung (embryology) Mice Micromonospora (metabolism) Naphthacenes (biosynthesis, isolation & purification, pharmacology)

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