Acute toxicity of 12,13-epoxytrichothecenes in one-day-old broiler chicks.

Abstract

Acute toxic effects of several 12,13-epoxytrichothecenes were investigated in 1-day-old broiler chicks by single oral doses. The 7-day median lethal dose values of purified 8-acetylneosolaniol, diacetoxyscirpenol, T-2 toxin, HT-2 toxin, neosolaniol, deacetyl-HT-2 toxin, and T-2 tetraol were 3.22 +/- 0.26, 3.82 +/- 0.40, 4.97 +/- 0.44, 7.22 +/- 0.39, 24.87 +/- 2.64, 30.18 +/- 7.53 (incomplete value), and 33.79 +/- 5.39 mg/kg of body weight, respectively. Deaths occurred during the 8- to 60-h period after dosing with the tested trichothecenes. Within 4 to 10 h after dosing, inappetence, asthenia, diarrhea, and coma generally developed. Sublethal doses of each toxin decreased feed consumption and weight gain proportionally with the amounts of toxins administered. These results demonstrate that the toxic potency of 12,13-epoxytrichothecenes varies depending on the modification of side chains in the molecule.

• Authors: M S Chi, T S Robison, C J Mirocha, K R Reddy
• Journal: Applied and environmental microbiology (Appl Environ Microbiol) Vol. 35 Issue 4 Pg. 636-40 (Apr 1978) ISSN: 0099-2240 [Print] United States
• PMID: 646352 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Sesquiterpenes
• Trichothecenes

Topics

• Administration, Oral
• Animals
• Chemical Phenomena
• Chemistry
• Chickens
• Dose-Response Relationship, Drug
• Lethal Dose 50
• Sesquiterpenes (toxicity)
• Trichothecenes (toxicity)