Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride.

Abstract	Eight calves and 15 steers were artificially infected with Anaplasma marginale. When parasitaemia reached 15 per cent, groups of animals were treated with either gloxazone (356C61), or imidocarb dihydrochloride or left untreated as controls. Both compounds were highly effective in the therapy of anaplasmosis. Toxicological studies showed that gloxazone was unacceptably toxic in lactating cattle and also caused nephrotoxicity in rats. Development work with gloxazone as an anaplasmacide has, therefore, been terminated but imidocarb is available.
Authors	N McHardy, J Berger, R J Taylor, D Farebrother, J A James
Journal	Research in veterinary science (Res Vet Sci) Vol. 29 Issue 2 Pg. 198-202 (Sep 1980) ISSN: 0034-5288 [Print] England
PMID	6451008 (Publication Type: Comparative Study, Journal Article)
Chemical References	Carbanilides Thiosemicarbazones Imidocarb
Topics	Anaplasmosis (drug therapy, microbiology) Animals Blood (microbiology) Carbanilides (therapeutic use) Cattle Cattle Diseases (chemically induced, drug therapy, microbiology) Imidocarb (therapeutic use) Rats Recurrence Sheep Sheep Diseases (chemically induced) Thiosemicarbazones (therapeutic use, toxicity)

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