Assessment of antitussive effects by citric acid threshold.

Abstract

The cough threshold to citric acid inhalation was measured in eight subjects by single inhalations of increasing concentrations of citric acid until a cough was consistently produced. The cough threshold was measured before and after 60 mg glaucine, 60 mg codeine and matched placebo on three separate days a week apart. Base-line cough threshold in each subject was consistent from week to week. Codeine increased the threshold by more than one citric acid concentration in three subjects. Placebo and glaucine did not produce a threshold change of more than one citric acid concentration. We conclude that the citric acid threshold is a simple measure of antitussive activity. No such activity was found with glaucine.

• Authors: P J Rees, T J Clark
• Journal: British journal of diseases of the chest (Br J Dis Chest) Vol. 77 Issue 1 Pg. 94-7 (Jan 1983) ISSN: 0007-0971 [Print] England
• PMID: 6344901 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antitussive Agents
• Aporphines
• Citrates
• Citric Acid
• glaucine
• Codeine

Topics

• Adult
• Antitussive Agents (therapeutic use)
• Aporphines (therapeutic use)
• Bronchial Provocation Tests
• Citrates
• Citric Acid
• Clinical Trials as Topic
• Codeine (therapeutic use)
• Cough (chemically induced)
• Double-Blind Method
• Humans
• Male